Die deutsche Laborlandschaft zu Diagnostik und Antibiotikaresistenztestung bei Neisseria gonorrhoeae

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• 作者：Anna Loenenbach M.A. ; M.Sc.…
• 关键词：Neisseria gonorrhoeae ; Sexuell übertragbare Infektionen ; Diagnostikmethoden ; Antibiotikaresistenz ; Resistenztestung ; Neisseria gonorrhoeae ; Sexually transmitted infections ; Antimicrobial resistance ; Diagnostic methods ; Resistance testing
• 刊名：Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：58
• 期：8
• 页码：866-874
• 全文大小：1,102 KB
• 参考文献：1.Ndowa F, Lusti-Narasimhan M (2012) The threat of untreatable gonorrhoea: implications and consequences for reproductive and sexual morbidity. Reprod Health Matters 20(40):76-2PubMed View Article
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  3.Unemo M, European STIGEB (2012) The 2012 European guideline on the diagnosis and treatment of gonorrhoea in adults recommends dual antimicrobial therapy. Euro Surveill 17(47)
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  10.Unemo M (2014) Challenges with antimicrobial susceptibility testing for Neisseria gonorrhoeae in the era of extensively drug-resistant gonorrhoea -molecular antimicrobial resistance testing crucial. Pathog Glob Health 108(5):214-15PubMed Central PubMed View Article
  11.Word Health Organization (WHO) (2014) Antimicrobial resistance: global report on surveillance 2014. http://?www.?who.?int/?drugresistance/?documents/?surveillancerepo?rt/?en/-/span> . Zugegriffen: 23. Juli. 2014
  12.European Centre for Disease Prevention and Control (ECDC) (2012) Response plan to control and manage the threat of multidrug-resistant gonorrhoea in Europe. http://?www.?ecdc.?europa.?eu/?en/?publications/?Publications/-206-ECDC-MDR-gonorrhoea-response-plan.?pdf . Zugegriffen: 18. Okt. 2013
  13.Unemo M, Shafer WM (2014) Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future. Clin Microbiol Rev 27(3):587-13PubMed Central PubMed View Article
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  15.Deutsche STI-Gesellschaft e.?V. (DSTIG) (2013) Leitlinie -Gonorrhoe bei Erwachsenen und Adoleszenten. http://?www.?awmf.?org/?uploads/?tx_?szleitlinien/-59-04l_?S25_?Gonorrhoe_?bei_?Erwachsenen_?Adoleszenten_-014-1_-1.?pdf . Zugegriffen: 10. Nov. 2014
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  22.Word Health Or
• 作者单位：Anna Loenenbach M.A., M.Sc. (1)
  S. Dudareva-Vizule (1)
  S. Buder (2)
  A. Sailer (1)
  P.K. Kohl (2)
  V. Bremer (1)
  
  1. Abteilung für Infektionsepidemiologie, Fachgebiet HIV/AIDS und andere sexuell oder durch Blut übertragbare Infektionen, Robert Koch-Institut, Seestra?e 10, 13353, Berlin, Deutschland
  2. Konsiliarlabor für Gonokokken, Vivantes Klinikum Neuk?lln, Rudower Stra?e 48, 12351 Berlin, Deutschland
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  General Practice and Family Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1437-1588

文摘

Recent years have seen a world-wide increase in antimicrobial resistance (AMR) in cases of infection with Neisseria gonorrhoeae (NG). NG infection is not notifiable in Germany and there is a lack of information available about the spread and AMR of NG infections. The objective of the study was to provide information on diagnostic methods and AMR testing in cases of NG infections in German laboratories. A cross-sectional survey was undertaken in Germany between June and August 2013 using an online questionnaire. Laboratories performing NG diagnostics were identified and described with regard to the diagnostic methods used, the number of tests performed, the antibiotics tested and the AMR observed, in addition to general laboratory information. In total, 188 of the 521 participating laboratories performed NG diagnostics; these were included in the further statistical analysis. 92.6- of the 188 laboratories performed culture. A median of 60 (IQR 15-70) samples per quarter (SPQ) were tested, with an overall positivity rate of 4.1 and 6.9- among men. Most (82.1-) of the 151 laboratories performing NG culture tested for AMR as well. The most frequently tested antibiotics were ciprofloxacin (94.8-), penicillin (93.1-), doxycycline (70.0-) and ceftriaxone (67.2-). The most frequently observed AMR ever were those against ciprofloxacin (87.1-), penicillin (78.3-), doxycycline (56.6-) and azithromycin (35.1-; all percentages refer to laboratories). The laboratories used different standards regarding susceptibility criteria. The emergence and spread of AMR shows that it is crucial to assess and monitor the scope and trends of multidrug-resistant gonorrhea. The data collected on diagnostic methods and AMR testing in cases of NG infections in German laboratories constitute an important basis for future monitoring.