Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model

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• 作者：Sachin S. Sakat (1)
  Kamaraj Mani (1)
  Yulia O. Demidchenko (2)
  Evgeniy A. Gorbunov (2)
  Sergey A. Tarasov (2)
  Archna Mathur (1)
  Oleg I. Epstein (2)
  
• 关键词：diclofenac ; carrageenan ; edema ; anti ; inflammatory
• 刊名：Inflammation
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：37
• 期：1
• 页码：1-9
• 全文大小：478 KB
• 作者单位：Sachin S. Sakat (1)
  Kamaraj Mani (1)
  Yulia O. Demidchenko (2)
  Evgeniy A. Gorbunov (2)
  Sergey A. Tarasov (2)
  Archna Mathur (1)
  Oleg I. Epstein (2)
  
  1. Dabur Research Foundation, 22, Site IV, Sahibabad, 201-010, Ghaziabad, Uttar Pradesh, India
  2. ООО “NPF “MATERIA MEDICA HOLIDING- 3rd Samotyochny per., 9, 127473, Moscow, Russian Federation
  
• ISSN：1573-2576

文摘

The study was aimed to investigate the effect of technologically treated diclofenac (release-active dilutions of diclofenac (RAD of diclofenac)) on anti-inflammatory activity of diclofenac in carrageenan-induced rat paw edema model. Ninety male Wistar albino rats (6-?weeks) divided into nine groups (n--0) were used. Anti-inflammatory activity was assessed at 1, 2, 3, 4, and 6?h after subplantar injection of carrageenan (0.1?ml of a 1?% solution in normal saline). Diclofenac alone was studied at 5 and 20?mg/kg, RAD of diclofenac alone at 7.5?ml/kg and their combination at 5 and 7.5?ml/kg, respectively. Diclofenac reduced (p-lt;-.05 at least) paw edema at all time points. RAD of diclofenac enhanced (p-lt;-.05) anti-inflammatory effect of diclofenac (5?mg/kg) at 2, 4, and 6?h on concurrent and at 2 and 4?h on sequential administration. Moreover at 2?h, anti-inflammatory effect of combination treatment reached values comparable to those of diclofenac (20?mg/kg). In conclusion, RAD of diclofenac enhanced anti-inflammatory effect of diclofenac.