WNT-5A: signaling and functions in health and disease

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• 作者：Kuldeep Kumawat ; Reinoud Gosens
• 关键词：Transcription ; Receptors ; Embryogenesis ; Migration ; Differentiation ; Fibrosis ; Cancer ; Inflammation
• 刊名：Cellular and Molecular Life Sciences (CMLS)
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：73
• 期：3
• 页码：567-587
• 全文大小：1,365 KB
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• 作者单位：Kuldeep Kumawat (1) (2)
  Reinoud Gosens (1) (2)
  
  1. Department of Molecular Pharmacology, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
  2. Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, The Netherlands
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Biomedicine
  Life Sciences
  Biochemistry
  
• 出版者：Birkh盲user Basel
• ISSN：1420-9071

文摘

WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present extensive structural malformations. WNT-5A predominantly activates β-catenin-independent WNT signaling cascade but can also activate β-catenin signaling to relay its diverse cellular effects such as cell polarity, migration, proliferation, cell survival, and immunomodulation. Moreover, aberrant WNT-5A signaling is associated with several human pathologies such as cancer, fibrosis, and inflammation. Thus, owing to its diverse functions, WNT-5A is a crucial signaling molecule currently under intense investigation with efforts to not only delineate its signaling mechanisms and functions in physiological and pathological conditions, but also to develop strategies for its therapeutic targeting. Keywords Transcription Receptors Embryogenesis Migration Differentiation Fibrosis Cancer Inflammation