Would it be too late? A retrospective case–control analysis to evaluate maternal–fetal outcomes in advanced maternal age
详细信息 查看全文
- 作者：Leonarda Ciancimino (1)
Antonio Simone Laganà (1)
Benito Chiofalo (1)
Roberta Granese (1)
Roberta Grasso (1)
Onofrio Triolo (1) - 关键词：Advanced maternal age ; Maternal–fetal outcomes ; Pregnancy ; Delivery ; Obstetric diseases
- 刊名：Archives of Gynecology and Obstetrics
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：290
- 期：6
- 页码：1109-1114
- 全文大小：199 KB
- 参考文献：1. Carolan M, Frankowska D (2011) Advanced maternal age and adverse perinatal outcome: a review of the evidence. Midwifery 27:793-01 p://dx.doi.org/10.1016/j.midw.2010.07.006" target="_blank" title="It opens in new window">CrossRef
2. Chan BC, Lao TT (2008) Effect of parity and advanced maternal age on obstetric outcome. Int J Gynaecol Obstet 102:237-41 p://dx.doi.org/10.1016/j.ijgo.2008.05.004" target="_blank" title="It opens in new window">CrossRef
3. Jacobsson B, Ladfors L, Milsom I (2004) Advanced maternal age and adverse perinatal outcome. Obstet Gynecol 104:727-33 p://dx.doi.org/10.1097/01.AOG.0000140682.63746.be" target="_blank" title="It opens in new window">CrossRef
4. Joseph KS, Allen AC, Dodds L, Turner LA, Scott H, Liston R (2005) The perinatal effects of delayed childbearing. Obstet Gynecol 105:1410-418 p://dx.doi.org/10.1097/01.AOG.0000163256.83313.36" target="_blank" title="It opens in new window">CrossRef
5. Aliyu MH, Salihu HM, Wilson RE, Alio AP, Kirby RS (2008) The risk of intrapartum stillbirth among smokers of advanced maternal age. Arch Gynecol Obstet 278:39-5 p://dx.doi.org/10.1007/s00404-007-0529-8" target="_blank" title="It opens in new window">CrossRef
6. Delbaere I, Verstraelen H, Goetgeluk S, Martens G, De Backer G, Temmerman M (2007) Pregnancy outcome in primiparae of advanced maternal age. Eur J Obstet Gynecol Reprod Biol 135:41-6 p://dx.doi.org/10.1016/j.ejogrb.2006.10.030" target="_blank" title="It opens in new window">CrossRef
7. Hoffman MC, Jeffers S, Carter J, Duthely L, Cotter A, González-Quintero VH (2007) Pregnancy at or beyond age 40?years is associated with an increased risk of fetal death and other adverse outcomes. Am J Obstet Gynecol 196:e11–e13 p://dx.doi.org/10.1016/j.ajog.2006.10.862" target="_blank" title="It opens in new window">CrossRef
8. Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M (2000) Maternal age and fetal loss: population based register linkage study. BMJ 320:1708-712 p://dx.doi.org/10.1136/bmj.320.7251.1708" target="_blank" title="It opens in new window">CrossRef
9. Kuliev A, Cieslak J, Verlinsky Y (2005) Frequency and distribution of chromosome abnormalities in human oocytes. Cytogenet Genome Res 111:193-98 p://dx.doi.org/10.1159/000086889" target="_blank" title="It opens in new window">CrossRef
10. Pellestor F, Anahory T, Hamamah S (2005) Effect of maternal age on the frequency of cytogenetic abnormalities in human oocytes. Cytogenet Genome Res 111:206-12 p://dx.doi.org/10.1159/000086891" target="_blank" title="It opens in new window">CrossRef
11. Hunt PA, Hassold TJ (2008) Human female meiosis: what makes a good egg go bad? Trends Genet 24:86-3 p://dx.doi.org/10.1016/j.tig.2007.11.010" target="_blank" title="It opens in new window">CrossRef
12. Janssens S, Wallace KL, Chang AM (2008) Prepartum and intrapartum caesarean section rates at Mater Mothers-Hospital Brisbane 1997-005. Aust N Z J Obstet Gynaecol 48:564-69 p://dx.doi.org/10.1111/j.1479-828X.2008.00920.x" target="_blank" title="It opens in new window">CrossRef
13. Bell JS, Campbell DM, Graham WJ, Penney GC, Ryan M, Hall MH (2001) Can obstetric complications explain the high levels of obstetric interventions and maternity service use among older women? A retrospective analysis of routinely collected data. BJOG 108:910-18
14. Rosenthal AN, Paterson-Brown S (1998) Is there an incremental rise in the risk of obstetric intervention with increasing maternal age? Br J Obstet Gynaecol 105:1064-069 p://dx.doi.org/10.1111/j.1471-0528.1998.tb09937.x" target="_blank" title="It opens in new window">CrossRef
15. Khoshnood B, Bouvier-Colle MH, Leridon H, Blondel B (2008) Impact of advanced maternal age on fecundity and women’s and children’s health. J Gynecol Obstet Biol Reprod (Paris) 37:733-47 p://dx.doi.org/10.1016/j.jgyn.2008.08.007" target="_blank" title="It opens in new window">CrossRef
16. Tough SC, Newburn-Cook C, Johnston DW, Svenson LW, Rose S, Belik J (2002) Delayed childbearing and its impact on population rate changes in lower birth weight, multiple birth, and preterm delivery. Pediatrics 109:399-03 p://dx.doi.org/10.1542/peds.109.3.399" target="_blank" title="It opens in new window">CrossRef
17. United Nations Economic Commission for Europe (2005) Trends in Europe and North America: the statistical yearbook of the Economic Commission for Europe 2005. The Commission, Geneva
18. Johnson JA, T - 作者单位：Leonarda Ciancimino (1)
Antonio Simone Laganà (1)
Benito Chiofalo (1)
Roberta Granese (1)
Roberta Grasso (1)
Onofrio Triolo (1)
1. Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, A.O.U. “G. Martino- University of Messina, Via C. Valeria 1, 98125, Messina, Italy - ISSN：1432-0711
文摘
Purpose To evaluate maternal–fetal outcomes in women of advanced maternal age (AMA; >35?years old) and women of physiological maternal age as controls (C; Methods Single-center, retrospective case–control analysis, from January 1 to December 31, 2013. For each group, we evaluated obstetric history, number of twin pregnancies, delivery mode, incidence of obstetric diseases and neonatal outcomes (5-min Apgar score, neonatal weight, meconium stained fluid rate, admission to the neonatal intensive care unit rate, and incidence of congenital malformations). Data are presented as n (%) and analyzed with χ 2 test and Fisher exact test (when required). A p value? Results We enrolled 1,347 pregnant women, 210 (15.6?%) in AMA and 1,137 (84.4?%) C. AMA patients showed a higher rate of previous (anamnestic) spontaneous abortion (SA; p?=?0.001; OR?=?2.10) and previous (anamnestic) voluntary pregnancy termination (p?=?0.022; OR?=?1.59), iterative cesarean section (p?=?0.026; OR?=?2.33), SA (p?=?0.001; OR?=?12.82), preterm delivery (p?=?0.001; OR?=?69.84), congenital malformations (p?=?0.036; OR?=?3.94). In C there was a greater number of nulliparous (p?=?0.009; OR?=?0.52) and vaginal deliveries (p?=?0.025; OR?=?0.41). There were not any statistically significant differences between the two groups for twin pregnancies (p?=?0.862; OR?=?0.97), first cesarean section (p?=?0.145; OR?=?0.95), other obstetric diseases and neonatal outcomes. Conclusion AMA could be considered an important risk factor only for SA and PTD and does not influence neonatal outcomes except for congenital malformations.