文摘
Purpose To evaluate maternal–fetal outcomes in women of advanced maternal age (AMA; >35?years old) and women of physiological maternal age as controls (C; Methods Single-center, retrospective case–control analysis, from January 1 to December 31, 2013. For each group, we evaluated obstetric history, number of twin pregnancies, delivery mode, incidence of obstetric diseases and neonatal outcomes (5-min Apgar score, neonatal weight, meconium stained fluid rate, admission to the neonatal intensive care unit rate, and incidence of congenital malformations). Data are presented as n (%) and analyzed with χ 2 test and Fisher exact test (when required). A p value? Results We enrolled 1,347 pregnant women, 210 (15.6?%) in AMA and 1,137 (84.4?%) C. AMA patients showed a higher rate of previous (anamnestic) spontaneous abortion (SA; p?=?0.001; OR?=?2.10) and previous (anamnestic) voluntary pregnancy termination (p?=?0.022; OR?=?1.59), iterative cesarean section (p?=?0.026; OR?=?2.33), SA (p?=?0.001; OR?=?12.82), preterm delivery (p?=?0.001; OR?=?69.84), congenital malformations (p?=?0.036; OR?=?3.94). In C there was a greater number of nulliparous (p?=?0.009; OR?=?0.52) and vaginal deliveries (p?=?0.025; OR?=?0.41). There were not any statistically significant differences between the two groups for twin pregnancies (p?=?0.862; OR?=?0.97), first cesarean section (p?=?0.145; OR?=?0.95), other obstetric diseases and neonatal outcomes. Conclusion AMA could be considered an important risk factor only for SA and PTD and does not influence neonatal outcomes except for congenital malformations.