Influence of high level of antibodies to myelin basic protein in female mice on the postnatal development and behavioral reactions of the progeny
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- 作者：S. G. Morozov ; I. E. Gribova ; T. P. Klushnik ; A. A. Sidyakin ; B. B. Gnedenko ; I. Yu. Toropygin ; D. A. Fadeev ; S. A. Zozulya ; E. I. Kovernaya and Z. V. Sarmanova
- 关键词：myelin basic protein ; immunization ; antibodies ; behavioral reactions of mice
- 刊名：Bulletin of Experimental Biology and Medicine
- 出版年：2007
- 出版时间：October, 2007
- 年：2007
- 卷：144
- 期：4
- 页码：551-554
- 全文大小：529.1 KB
文摘
Physical development, behavioral reactions, and training capacity were studied in the progeny of female BALB/c mice with high levels of antibodies to myelin basic protein. The proposed protocol of immunization ensures high levels of antibodies to myelin basic protein in this mouse strain. High level of antibodies to myelin basic protein in pregnant females causes an increase in the blood level of these antibodies in the progeny. Inhibitory effect of antibodies to myelin basic protein on physical development, training process, and memory in mouse pups was detected.