参考文献:Chen GT, Yang M, Song Y et al (2008) Microbial transformation of ginsenoside Rb1 by Acremonium strictum. Appl Microbiol Biotechnol 77:1345鈥?350CrossRef PubMed Chen GT, Yang X, Nong SJ et al (2013) Two novel hydroperoxylated products of 20(S)-protopanaxadiol produced by Mucor racemosus and their cytotoxic activities against human prostate cancer cells. Biotechnol Lett 35:439鈥?43CrossRef PubMed Gandomkar S, Habibi Z (2014) Biotransformation of 6伪-santonin and 1,2-dihudro-伪-santonin by Acremonium chrysogenum PTCC 5271 and Rhizomoucor pusillus PTCC 5134. J Mol Catal B 110:59鈥?3CrossRef Hasegawa H (2004) Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid. J Pharmacol Sci 95:153鈥?57CrossRef PubMed He C, Zhou D, Li J et al (2014) Identification of 20(S)-protopanaxatriol metabolites in rats by ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry and nuclear magnetic resonance spectroscopy. J Pharmaceut Biomed 88:497鈥?08CrossRef Lian X, Zhang Z, Stringer J (2006) Anticonvulsant and neuroprotective effects of ginsenosides in rats. Epilepsy Res 70:244鈥?56CrossRef PubMed Marumoto S, Miyazawa M (2010) Biotransformation of isoimperatorin and imperatorin by Glomerella cingulata and & 尾-secretase inhibitory activity. Bioorg Med Chem 18:455鈥?59CrossRef PubMed Muffler K, Leipolda D, Schellera MC et al (2011) Biotransformation of triterpenes. Proc Biochem 46:1鈥?5CrossRef Popovich DG, Kitts DD (2002) Structure鈥揻unction relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line. Arch Biochem Biophys 406:1鈥?CrossRef PubMed Popovich DG, Kitts DD (2004) Mechanistic studies on protopanaxadiol, Rh2, and ginseng (Panax quinquefolius) extract induced cytotoxicity in intestinal Caco-2 cells. J Biochem Mol Toxicol 18:143鈥?49CrossRef PubMed Sargent JM, Taylor CG (1989) Appraisal of the MTT assay as a rapid test of chemosensitivity in acute myeloid-leukemia. Br J Cancer 60:206鈥?10PubMed Central CrossRef PubMed Shibata SJ (2001) Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. J Korean Med Sci 16:S28鈥揝37PubMed Central CrossRef PubMed Tian Y, Guo HZ, Han J et al (2005) Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosus. J Nat Prod 68:678鈥?80CrossRef PubMed Yao ML, Liu JZ, Jin S et al (2014) A novel biotransformation of astragalosides to astragaloside IV with the deacetylation of fungal endophyte Penicillium canescene. Proc Biochem 49:807鈥?12CrossRef Zhang J, Guo HZ, Tian Y et al (2007) Biotransformation of 20(S)-protopanaxatriol by Mucor spinosus and the cytotoxic structure activity relationships of the transformed products. Phytochemistry 68:2523鈥?530CrossRef PubMed
作者单位:Guangtong Chen (1) (2) Hongjuan Ge (1) Yan Song (1) Jianlin Li (1) Xuguang Zhai (1) Juanjuan Wu (1) Xiang Ling (1)
1. School of Pharmacy, Nantong University, Nantong, 226001, People鈥檚 Republic of China 2. Faculty of Chemistry and Chemical Biology, Institute of Environmental Research (INFU), TU Dortmund, 44221, Dortmund, Germany