XPC Lys939Gln and Ala499Val polymorphisms in colorectal cancer susceptibility: a meta-analysis of case–control studies

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• 作者：Chuan Liu (1)
  Qinghua Yin (2)
  Mingzhen Ying (1)
  Junhui Lin (1)
  Lian Li (2)
  Guangjun Jiao (3)
  Mei Wang (1)
  Yajie Wang (1)
  
• 关键词：Meta ; analysis ; XPC ; Polymorphisms ; Colorectal cancer
• 刊名：Molecular Biology Reports
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：41
• 期：2
• 页码：1171-1178
• 全文大小：401 KB
• 作者单位：Chuan Liu (1)
  Qinghua Yin (2)
  Mingzhen Ying (1)
  Junhui Lin (1)
  Lian Li (2)
  Guangjun Jiao (3)
  Mei Wang (1)
  Yajie Wang (1)
  
  1. Department of Oncology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, People’s Republic of China
  2. Yueyang Second People’s Hospital, Yueyang, People’s Republic of China
  3. Musculoskeletal Tumor Center, People’s Hospital, Peking University, Beijing, People’s Republic of China
  
• ISSN：1573-4978

文摘

The XPC Lys939Gln and Ala499Val polymorphisms were likely to be involved with the development of colorectal cancer. However, there had been inconsistent reports of association. This meta-analysis of literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase and Web of Science for relevant articles with a time limit of December 2012. The strength of association between the XPC Lys939Gln and Ala499Val polymorphisms and colorectal cancer susceptibility were assessed by odds ratio (OR) with the corresponding 95?% confidence interval (95?% CI). This meta-analysis including six case–control studies evaluated the associations between the two XPC polymorphisms (Lys939Gln, Ala499Val) and colorectal cancer susceptibility. For XPC Lys939Gln, no obvious associations were found for all genetic models [CC vs AA: OR (95?% CI)?=?1.12 (0.94-.32); CA vs AA: OR (95?% CI)?=?1.08 (0.94-.24); the dominant model: OR (95?% CI)?=?1.09 (0.97-.23); the recessive model: OR (95?% CI)?=?1.07 (0.92-.25)]. For XPC Ala499Val, no obvious associations were also not found for all genetic models [TT vs CC: OR (95?% CI)?=?0.84 (0.65-.10); CT vs CC: OR (95?% CI)?=?1.00 (0.86-.15); the dominant model: OR (95?% CI)?=?0.98 (0.85-.12); the recessive model: OR (95?% CI)?=?0.87 (0.67-.12)]. This meta-analysis suggested that both the XPC Lys939Gln and Ala499Val polymorphisms were not risk factors for increasing colorectal cancer.