Synthesis, DNA-binding properties and cytotoxicity evaluation of two copper(II) complexes based on curcumin

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• 作者：Xuan Xue ; Jiafeng Wang ; Guifu Si ; Chengming Wang…
• 刊名：Transition Metal Chemistry
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：41
• 期：3
• 页码：331-337
• 全文大小：820 KB
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• 作者单位：Xuan Xue (1) (3)
  Jiafeng Wang (1) (2)
  Guifu Si (1)
  Chengming Wang (1) (3)
  Shuangsheng Zhou (1) (2)
  
  1. Department of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China
  3. National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, 230026, China
  2. Anhui Province Key Laboratory of Environment-friendly Polymer Materials, Anhui University, Hefei, 230601, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Catalysis
  Physical Chemistry
  Inorganic Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1572-901X

文摘

Two Cu(II) complexes based on curcumin, namely CuL ₂ 1 [HL1 = 1,7-bis[4-(2-oxymethylenepyridine)-3-methoxyl]phenyl-1,6-heptadiene-3,5-diketone] and CuL ₂ 2 [HL2 = 1,7-bis[4-(3-oxymethylene-2-chlorothiophene)-3-methoxyl] phenyl-1,6-heptadiene-3,5-diketone], have been synthesized and characterized by physico-chemical and spectroscopic methods. The interactions of calf thymus DNA (CT-DNA) with both complexes have been investigated by UV–Vis absorption, fluorescence and viscosity titration methods. Both complexes are found to interact with CT-DNA by intercalative binding modes. Evaluation of the cytotoxicities of the complexes against three human tumor cells showed that they have potent cytotoxicities against all three cell lines.