Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer

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• 作者：Jingxin Feng ; Guiying Xu ; Jiwei Liu ; Na Zhang…
• 关键词：LSD1 ; Phosphorylation ; EMT ; Breast cancer ; Metastasis
• 刊名：Breast Cancer Research and Treatment
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：159
• 期：3
• 页码：443-456
• 全文大小：7,356 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7217
• 卷排序：159

文摘

PurposeLSD1 is overexpressed in various cancers including breast cancer, but its functional roles in tumourigenesis are not fully understood. This study aims at revealing the role of LSD1 in breast cancer development. In addition, it has been reported that phosphorylation of the Serine 112 residue of LSD1 by PKCα is crucial for its function in gene regulation. We also explored whether this phosphorylation affects LSD1’s role in breast cancer development.