Development of part-dissolvable chitosan fibers with surface N-succinylation for wound care dressing

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• 作者：Guohui Sun ; Chao Feng ; Ming Kong ; Xiaojie Cheng…
• 关键词：chitosan fiber ; surface N ; succinylation ; liquor absorptivity ; part dissolvability ; wound dressing
• 刊名：Frontiers of Materials Science
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：9
• 期：3
• 页码：272-281
• 全文大小：3,681 KB
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• 作者单位：Guohui Sun (1)
  Chao Feng (1)
  Ming Kong (1)
  Xiaojie Cheng (1)
  Jiaojiao Bing (1)
  Guixue Xia (1)
  Zixian Bao (1)
  Hyunjin Park (2)
  Xiguang Chen (1)
  
  1. College of Marine Life Science, Ocean University of China, Qingdao, 266003, China
  2. College of Life Sciences and Biotechnology, Korea University, Seoul, 136-701, Korea
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Materials Science
  Chemistry
  Chinese Library of Science
  
• 出版者：Higher Education Press, co-published with Springer-Verlag GmbH
• ISSN：2095-0268

文摘

To enhance the liquor absorptivity of chitosan fibers (CS-Fs), N-succinyl surface-modified chitosan fibers (NSCS-Fs) were developed and evaluated for wound healing. The NSCS-Fs exhibited cracks on the surface and high liquor absorbing capacity with absorbing–dissolvable equilibrium state in phosphate buffer solution (PBS). The bacteriostasis ratios of NSCS-Fs against E. coli, S. aureus and C. albicans were higher than 80%. No cytotoxicity has been found for mouse embryo fibroblasts (MEFs) treated with NSCS-Fs leach liquor. Acute oral toxicity and skin irritation experiment were taken to evaluate the safety of NSCS-Fs in vitro. Muscle implant study showed that NSCS-Fs were biodegradable and non-toxic in vivo. These results suggested that the surface modified NSCS-Fs had favorable biological properties and improved liquor absorptivity, indicating that they could be used as promising dressing materials for wound care.