Methylmalonic acid administration induces DNA damage in rat brain and kidney
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- 作者：Vanessa M. Andrade (1)
Hugo S. Dal Pont (2)
Daniela D. Leffa (1)
Adriani P. Damiani (1)
Giselli Scaini (3)
Giana Hainzenreder (1)
Emilio L. Streck (3)
Gustavo C. Ferreira (2)
Patrícia F. Schuck (2) - 关键词：Methylmalonic aciduria ; Methylmalonic acid ; Renal failure ; DNA damage ; Brain damage
- 刊名：Molecular and Cellular Biochemistry
- 出版年：2014
- 出版时间：June 2014
- 年：2014
- 卷：391
- 期：1-2
- 页码：137-145
- 全文大小：
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Hugo S. Dal Pont (2)
Daniela D. Leffa (1)
Adriani P. Damiani (1)
Giselli Scaini (3)
Giana Hainzenreder (1)
Emilio L. Streck (3)
Gustavo C. Ferreira (2)
Patrícia F. Schuck (2)
1. Laboratório de Biologia Celular e Molecular, Programa de Pós-Gradua??o em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil
2. Laboratório de Erros Inatos do Metabolismo, Programa de Pós-Gradua??o em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Avenida Universitária, 1105, Bloco S, Sala 6, Criciúma, SC, CEP 88806-000, Brazil
3. Laboratório de Bioenergética, Programa de Pós-Gradua??o em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil - ISSN：1573-4919
文摘
Accumulation of methylmalonic acid (MMA) in tissues and biological fluids is the biochemical hallmark of methylmalonic aciduria. Affected patients present renal failure and severe neurological findings. Considering that the underlying pathomechanisms of tissue damage are not yet understood, in the present work we assessed the in vivo e in vitro effects of MMA on DNA damage in brain and kidney, as well as on p53 and caspase 3 levels, in the presence or absence of gentamicin (acute renal failure model). For in vitro studies, tissue prisms were incubated in the presence of different concentrations of MMA and/or gentamicin for one hour. For in vivo studies, animals received a single injection of gentamicin (70?mg/kg) and/or three injections of MMA (1.67?μmol/g; 11?h interval between injections). The animals were killed 1?h after the last MMA injection. Controls received saline in the same volumes. DNA damage was analyzed by the comet assay. We found that MMA and gentamicin alone or combined in vitro increased DNA damage in cerebral cortex and kidney of rats. Furthermore, MMA administration increased DNA damage in both brain and kidney. Gentamicin per se induced DNA damage only in kidney, and the association of MMA plus gentamicin also caused DNA damage in cerebral cortex and kidney. On the other hand, p53 and caspase 3 levels were not altered by the administration of MMA and/or gentamicin. Our findings provide evidence that DNA damage may contribute to the neurological and renal damage found in patients affected by methylmalonic aciduria.