Antinociceptive effects induced by intra-lateral habenula complex injection of the galanin receptor 1 agonist M617 in rats

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• 作者：Li-Bo Fu ; Ying Wang ; Xiao-Xiao Sun ; Xiao-Xia Liu ; Ying Wang…
• 关键词：Galanin ; M617 ; Galanin receptor 1 ; Antinociceptive effects ; Lateral habenula
• 刊名：Experimental Brain Research
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：234
• 期：2
• 页码：493-497
• 全文大小：866 KB
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• 作者单位：Li-Bo Fu (1)
  Ying Wang (1)
  Xiao-Xiao Sun (1)
  Xiao-Xia Liu (1)
  Ying Wang (1)
  Wen Zhuang (1)
  
  1. College of Life Science, ChangChun Normal University, Changchun, 130032, Jilin, People’s Republic of China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Neurology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1106

文摘

The present study was performed to explore the antinociceptive effects of the galanin receptor 1 agonist M617 in lateral habenula complex in rats. Intra-lateral habenula injection of 0.1, 0.5, 1 or 2 nmol of galanin induced dose-dependent increases in hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulations in rats. Furthermore, intra-lateral habenula injection of 0.1, 0.5, 1 or 2 nmol of the galanin receptor 1 agonist M617 also induced dose-dependent increases in HWLs to noxious thermal and mechanical stimulations in rats. Interestingly, there were no significant differences between the antinociceptive effects induced by intra-lateral habenula injection of 2 nmol of M617 and 2 nmol of galanin. The results indicate that galanin receptor 1 may be involved in the galanin-induced antinociceptive effects in the lateral habenula.