Perimetric and retinal nerve fiber layer findings in patients with Parkinson’s disease

详细信息    查看全文

• 作者：Evangelia E Tsironi (1)
  Anna Dastiridou (1)
  Andreas Katsanos (1)
  Efthymios Dardiotis (2)
  Stella Veliki (1)
  Gianna Patramani (2)
  Fani Zacharaki (1)
  Stella Ralli (2)
  Georgios M Hadjigeorgiou (2)
  
• 关键词：Visual loss ; Visual fields ; Parkinson's disease ; Retina ; Visual processing
• 刊名：BMC Ophthalmology
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：12
• 期：1
• 全文大小：413KB
• 参考文献：1. Chaudhuri KR, Schapira AH: Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment. / Lancet Neurol 2009, 8:464-74. CrossRef
  2. Jones RD, Donaldson IM, Timmings PL: Impairment of high-contrast visual acuity in Parkinson's disease. / Mov Disord 1992, 7:232-38. mds.870070308">CrossRef
  3. Silva MF, Faria P, Regateiro FS, Forjaz V, Januário C, Freire A, / et al.: Independent patterns of damage within magno-, parvo- and koniocellular pathways in Parkinson's disease. / Brain 2005, 128:2260-271. CrossRef
  4. Bodis-Wollner I, Marx MS, Mitra S, Bobak P, Mylin L, Yahr M: Visual dysfunction in Parkinson's disease Loss in spatiotemporal contrast sensitivity. / Brain 1987, 110:1675-698. CrossRef
  5. Armstrong RA: Visual symptoms in Parkinson's disease. / Parkinsons Dis 2011, 2011:908306.
  6. Archibald NK, Clarke MP, Mosimann UP, Burn DJ: The retina in Parkinson's disease. / Brain 2009, 132:1128-145. CrossRef
  7. Witkovsky P: Dopamine and retinal function. / Doc Ophthalmol 2004, 108:17-0. CrossRef
  8. Nguyen-Legros J: Functional neuroarchitecture of the retina: hypothesis on the dysfunction of retinal dopaminergic circuitry in Parkinson's disease. / Surg Radiol Anat 1988, 10:137-44. CrossRef
  9. Harnois C, Di Paolo T: Decreased dopamine in the retinas of patients with Parkinson's disease. / Invest Ophthalmol Vis Sci 1990, 31:2473-475.
  10. Inzelberg R, Ramirez JA, Nisipeanu P, Ophir A: Retinal nerve fiber layer thinning in Parkinson disease. / Vision Res 2004, 44:2793-797. CrossRef
  11. Altintas O, I?eri P, Ozkan B, Ca?lar Y: Correlation between retinal morphological and functional findings and clinical severity in Parkinson's disease. / Doc Ophthalmol 2008, 116:137-46. CrossRef
  12. Moschos MM, Tagaris G, Markopoulos I, Margetis I, Tsapakis S, Kanakis M, / et al.: Morphologic changes and functional retinal impairment in patients with Parkinson disease without visual loss. / Eur J Ophthalmol 2011, 21:24-9. CrossRef
  13. Swanson EA, Izatt JA, Hee MR, Huang D, Lin CP, Schuman JS, / et al.: In vivo retinal imaging by optical coherence tomography. / Opt Lett 1993, 18:1864-866. CrossRef
  14. Aaker GD, Myung JS, Ehrlich JR, Mohammed M, Henchcliffe C, Kiss S: Detection of retinal changes in Parkinson's disease with spectral-domain optical coherence tomography. / Clin Ophthalmol 2010, 4:1427-432.
  15. Archibald NK, Clarke MP, Mosimann UP, Burn DJ: Retinal thickness in Parkinson's disease. / Parkinsonism Relat Disord 2011, 17:431-36. CrossRef
  16. Albrecht P, Müller AK, Südmeyer M, Ferrea S, Ringelstein M, Cohn E, / et al.: Optical coherence tomography in parkinsonian syndromes. / PLoS One 2012,7(4):34891. Epub 2012 Apr 13 CrossRef
  17. Yenice O, Onal S, Midi I, Ozcan E, Temel A, I-Gunal D: Visual field analysis in patients with Parkinson's disease. / Parkinsonism Relat Disord 2008, 14:193-98. CrossRef
  18. Gelb DJ, Oliver E, Gilman S: Diagnostic criteria for Parkinson disease. / Arch Neurol 1999, 56:33-9. CrossRef
  19. Goldberg I, Graham SL, Klistorner AI: Multifocal objective perimetry in the detection of glaucomatous field loss. / Am J Ophthalmol 2002, 133:29-9. CrossRef
  20. Murdoch IE, Morris SS, Cousens SN: People and eyes: statistical approaches in ophthalmology. / Br J Ophthalmol 1998, 82:971-73. CrossRef
  21. Yavas GF, Yilmaz O, Küsbeci T, Oztürk F: The effect of levodopa and dopamine agonists on optic nerve head in Parkinson disease. / Eur J Ophthalmol 2007, 17:812-16.
  22. Hajee ME, March WF, Lazzaro DR, Wolintz AH, Shrier EM, Glazman S, / et al.: Inner retinal layer thinning in Parkinson disease. / Arch Ophthalmol 2009, 127:737-41. mol.2009.106">CrossRef
  23. Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, / et al.: Optical coherence tomography. / Science 1991, 254:1178-181. CrossRef
  24. Sung KR, Kim JS, Wollstein G, Folio L, Kook MS, Schuman JS: Imaging of the retinal nerve fibre layer with spectral domain optical coherence tomography for glaucoma diagnosis. / Br J Ophthalmol 2011, 95:909-14. CrossRef
  25. Wojtkowski M, Srinivasan V, Fujimoto JG, Ko T, Schuman JS, Kowalczyk A, / et al.: Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography. / Ophthalmology 2005, 112:1734-746. CrossRef
  26. Nassif N, Cense B, Park BH, Yun SH, Chen TC, Bouma BE, / et al.: In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography. / Opt Lett 2004, 29:480-82. CrossRef
  27. Sehi M, Grewal DS, Sheets CW, Greenfield DS: Diagnostic ability of Fourier-domain vs time-domain optical coherence tomography for glaucoma detection. / Am J Ophthalmol 2009, 148:597-05. CrossRef
  28. Chang RT, Knight OJ, Feuer WJ, Budenz DL: Sensitivity and specificity of time-domain versus spectral-domain optical coherence tomography in diagnosing early to moderate glaucoma. / Ophthalmology 2009, 116:2294-299. CrossRef
  29. Moreno-Montanes J, Olmo N, Alvarez A, Garcia N, Zarranz-Ventura J: Cirrus high-definition optical coherence tomography compared with Stratus optical coherence tomography in glaucoma diagnosis. / Invest Ophthalmol Vis Sci 2010, 51:335-43. CrossRef
  30. Bayer AU, Keller ON, Ferrari F, Maag KP: Association of glaucoma with neurodegenerative diseases with apoptotic cell death: Alzheimer's disease and Parkinson's disease. / Am J Ophthalmol 2002, 133:135-37. CrossRef
  31. Bodis-Wollner I: Visual deficits related to dopamine deficiency in experimental animals and Parkinson's disease patients. / Trends Neurosci 1990, 13:296-02. CrossRef
  32. Djamgoz MB, Hankins MW, Hirano J, Archer SN: Neurobiology of retinal dopamine in relation to degenerative states of the tissue. / Vision Res 1997, 37:3509-529. CrossRef
  33. Peppe A, Stanzione P, Pierelli F, De Angelis D, Pierantozzi M, Bernardi G: Visual alterations in de novo Parkinson's disease: pattern electroretinogram latencies are more delayed and more reversible by levodopa than are visual evoked potentials. / Neurology 1995, 45:1144-148. CrossRef
  34. Gottlob I, Schneider E, Heider W, Skrandies W: Alteration of visual evoked potentials and electroretinograms in Parkinson's disease. / Electroencephalogr Clin Neurophysiol 1987, 66:349-57. CrossRef
  35. Langheinrich T, Elst L, Tebartz V, Lagrèze WA, Bach M, Lücking CH, / et al.: Visual contrast response functions in Parkinson's disease: evidence from electroretinograms, visually evoked potentials and psychophysics. / Clin Neurophysiol 2000, 111:66-4. CrossRef
  36. Nightingale S, Mitchell KW, Howe JW: Visual evoked cortical potentials and pattern electroretinograms in Parkinson's disease and control subjects. / J Neurol Neurosurg Psychiatry 1986, 49:1280-287. CrossRef
  37. Bodis-Wollner I, Yahr MD: Measurements of visual evoked potentials in Parkinson's disease. / Brain 1978, 101:661-71. CrossRef
  38. Shibasaki H, Tsuji S, Kuroiwa Y: Oculomotor abnormalities in Parkinson's disease. / Arch Neurol 1979, 36:360-64. CrossRef
  39. Wild JM, Pacey IE, Hancock SA, Cunliffe IA: Between-algorithm, between-individual differences in normal perimetric sensitivity: full threshold, FASTPAC, and SITA. Swedish Interactive Threshold algorithm. / Invest Ophthalmol Vis Sci 1999, 40:1152-161.
  40. Bengtsson B, Olsson J, Heijl A, Rootzén H: A new generation of algorithms for computerized threshold perimetry, SITA. / Acta Ophthalmol Scand 1997, 75:368-75. CrossRef
  41. Dalrymple-Alford JC, MacAskill MR, Nakas CT, Livingston L, Graham C, Crucian GP, / et al.: The MoCA: well-suited screen for cognitive impairment in Parkinson disease. / Neurology 2010,9(75):1717-725. CrossRef
  42. The pre-publication history for this paper can be accessed here:medcentral.com/1471-2415/12/54/prepub" class="a-plus-plus">http://www.biomedcentral.com/1471-2415/12/54/prepub
  
• 作者单位：Evangelia E Tsironi (1)
  Anna Dastiridou (1)
  Andreas Katsanos (1)
  Efthymios Dardiotis (2)
  Stella Veliki (1)
  Gianna Patramani (2)
  Fani Zacharaki (1)
  Stella Ralli (2)
  Georgios M Hadjigeorgiou (2)
  
  1. Department of Ophthalmology, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, Mezourlo, 41222, Larissa, Greece
  2. Department of Neurology, Faculty of Medicine, University Hospital of Larissa, University of Thessaly, Larissa, Greece
  

文摘

Background Visual dysfunction is common in Parkinson’s disease (PD). It remains, however, unknown whether it is related to structural alterations of the retina. The aim of this study is to compare visual field (VF) findings and circumpapillary retinal nerve fiber layer (RNFL) thickness in a series of PD patients and normal controls, in order to assess possible retinal anatomical changes and/or functional damage associated with PD. Methods PD patients and controls were recruited and underwent VF testing with static automated perimetry and RNFL examination with optical coherence tomography (OCT). Cognitive performance using Mini Mental State Examination (MMSE), PD staging using modified Hoehn and Yahr (H-Y) scale and duration of the disease was recorded in PD patients. Results One randomly selected eye from each of 24 patients and 24 age-matched controls was included. OCT RNFL thickness analysis revealed no difference in the inferior, superior, nasal or temporal sectors between the groups. The average peripapillary RNFL was also similar in the two groups. However, perimetric indices of generalized sensitivity loss (mean deviation) and localized scotomas (pattern standard deviation) were worse in patients with PD compared to controls (p-lt;-.01). 73% of eyes of PD patients had glaucomatous-like asymmetrical hemifield defects with abnormal Glaucoma Hemifield Test and various combinations of arcuate defects (n--2), nasal steps (n--1) and paracentral scotomas (n--6). Bilateral defects were found in 14 patients (58%). No correlation was found between VF indices and MMSE or H-Y scores. Conclusion PD patients may demonstrate glaucomatous-like perimetric defects even in the absence of decreased RNFL thickness.