Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial
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- 作者：Ayub Mpoya ; Sarah Kiguli ; Peter Olupot-Olupot ; Robert O. Opoka ; Charles Engoru…
- 关键词：Children ; Africa ; Anaemia ; Malaria ; Sepsis ; Transfusion ; Micronutrients ; Emergency medicine ; Haemoglobinopathies ; Antibiotic prophylaxis
- 刊名：Trials
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：16
- 期：1
- 全文大小：1,595 KB
- 刊物主题：Medicine/Public Health, general; Biomedicine general; Statistics for Life Sciences, Medicine, Health Sciences;
- 出版者：BioMed Central
- ISSN：1745-6215
文摘
Background In sub-Saharan Africa, where infectious diseases and nutritional deficiencies are common, severe anaemia is a common cause of paediatric hospital admission, yet the evidence to support current treatment recommendations is limited. To avert overuse of blood products, the World Health Organisation advocates a conservative transfusion policy and recommends iron, folate and anti-helminthics at discharge. Outcomes are unsatisfactory with high rates of in-hospital mortality (9–10 %), 6-month mortality and relapse (6 %). A definitive trial to establish best transfusion and treatment strategies to prevent both early and delayed mortality and relapse is warranted.