The role of autophagy induced by tumor microenvironment in different cells and stages of cancer

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• 作者：Xue Yang (1)
  Dan-Dan Yu (1)
  Fei Yan (1)
  Ying-Ying Jing (1)
  Zhi-Peng Han (1)
  Kai Sun (2)
  Lei Liang (1)
  Jing Hou (3)
  Li-Xin Wei (1)
  
  1. Tumor Immunology and Gene Therapy Center ; Eastern Hepatobiliary Surgery Hospital ; The Second Military Medical University ; 225 Changhai Road ; 200438 ; Shanghai ; China
  2. Central laboratory ; Ren Ji Hospital ; School of Medicine ; Shanghai JiaoTong University ; Shanghai ; China
  3. Department of Pharmacy ; Chang Hai Hospital ; The Second Military Medical University ; Shanghai ; China
  
• 关键词：Autophagy ; Tumor microenvironment ; Tumorigenesis
• 刊名：Cell & Bioscience
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：5
• 期：1
• 全文大小：1,347 KB
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• 刊物主题：Cell Biology; Microbiology;
• 出版者：BioMed Central
• ISSN：2045-3701

文摘

Development of a tumor is a very complex process, and invasion and metastasis of malignant tumors are hallmarks and are difficult problems to overcome. The tumor microenvironment plays an important role in controlling tumor fate and autophagy induced by the tumor microenvironment is attracting more and more attention. Autophagy can be induced by several stressors in the tumor microenvironment and autophagy modifies the tumor microenvironment, too. Autophagy has dual roles in tumor growth. In this review, we discussed the interaction between autophagy and the tumor microenvironment and the paradoxical roles of autophagy on tumor growth at different stages of tumor development.