Expression of interleukin-9 and its upstream stimulating factors in rats with ischemic stroke

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• 作者：Yinyao Lin ; Lei Zhang ; Yongqiang Dai ; Haiyan Li ; Yanqiang Wang…
• 关键词：Interleukin ; 9 ; Inflammation ; Acute ischemic stroke
• 刊名：Neurological Sciences
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：36
• 期：6
• 页码：913-920
• 全文大小：2,644 KB
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• 作者单位：Yinyao Lin (1)
  Lei Zhang (2)
  Yongqiang Dai (1)
  Haiyan Li (1)
  Yanqiang Wang (1)
  Bingjun Zhang (1)
  Suqin Chen (3)
  Zhengqi Lu (1)
  
  1. Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Guangzhou, Guangdong, China
  2. Department of Neurology, The Fifth Affiliated Hospital of Sun Yat-sen University, No. 52 Meihuadong Road, Zhuhai, Guangdong, China
  3. Department of Neurology, Hui Ya Hospital of The First Affiliated Hospital, Sun Yat-sen University, No. 186 Zhongxingbei Road, Huizhou, Guangdong, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Neuroradiology
  Neurosurgery
  Psychiatry
  
• 出版者：Springer Milan
• ISSN：1590-3478

文摘

To investigate the temporal expressions of IL-9 and its related cytokines after middle cerebral artery occlusion in rats. IL-9 and its related cytokines in ischemia brain and blood were tested after rats were subjected to transient focal ischemia. Comparing with sham-operated group, the levels of IL-4, TGF-β, PU.1, IRF4, OX40, NIK, RelB-p52 and IL-9 in experimental groups were significantly higher after middle cerebral artery occlusion. The results showed that expressions of IL-9 and its upstream stimulating factors increased in experimental stroke, and whether they play a role or just a secondary change is awaiting further research.