Cell therapy in diabetes: current progress and future prospects

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• 作者：Ying Wang ; Tang Hai ; Lei Liu ; Zhonghua Liu ; Qi Zhou
• 关键词：Diabetes ; Cell therapy ; Signaling pathway ; Xenotransplantation
• 刊名：Chinese Science Bulletin
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：60
• 期：20
• 页码：1744-1751
• 全文大小：627 KB
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• 作者单位：Ying Wang (1) (2)
  Tang Hai (2)
  Lei Liu (2)
  Zhonghua Liu (1)
  Qi Zhou (2)
  
  1. College of Life Sciences, Northeast Agricultural University of China, Harbin, 150030, China
  2. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China
  
• 刊物主题：Science, general; Life Sciences, general; Physics, general; Chemistry/Food Science, general; Earth Sciences, general; Engineering, general;
• 出版者：Springer Berlin Heidelberg
• ISSN：1861-9541

文摘

Diabetes mellitus, characterized by the impaired metabolism of insulin secretion in β cells, is becoming one of the most prevalent diseases around the world. Recently, cell replacement based on differentiation of various pluripotent stem cells, including embryonic stem cells, induced pluripotent stem cells and multipotent stem cells, such as bone marrow mesenchymal stem cells, adipose-derived stem cells and gnotobiotic porcine skin-derived stem cells, is becoming a promising therapeutic strategy. Cells derived from pancreatic tissues or other tissues that are relevant to β cell differentiation have also been used as cell source. However, in spite of hopeful experimental results, cell therapy in diabetes still confronts certain obstacles, such as purity of cells, functional differentiation of stem cells and possible tumorigenesis, which, in turn, lead to the seeking of new-generation tools, such as xenogenetic materials. In this review, we will summarize the current knowledge and future prospects of cell therapy in diabetes mellitus.