The neuritogenic and neuroprotective potential of senegenin against Aβ-induced neurotoxicity in PC 12 cells

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• 作者：Robert Jesky ; Hailong Chen
• 关键词：Neuritogenesis ; Neuroprotective ; Nootropic ; Cytotoxicity ; PC 12 cells ; Senegenin
• 刊名：BMC Complementary and Alternative Medicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：16
• 期：1
• 全文大小：1,796 KB
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• 作者单位：Robert Jesky (1)
  Hailong Chen (1)
  
  1. Department of General Surgery–Integrated traditional Chinese and Western medicine, 1st Affiliated Hospital of Dalian Medical University, No. 222, Zhongshan Road, Xigang District, Dalian, 116011, China
  
• 刊物主题：Complementary & Alternative Medicine; Internal Medicine; Chiropractic Medicine;
• 出版者：BioMed Central
• ISSN：1472-6882

文摘

Background Improved therapeutics aimed at ameliorating the devastating effects of neurodegenerative diseases, such as Alzheimer’s disease (AD), are pertinent to help attenuate their growing prevalence worldwide. One promising avenue for such therapeutics lies in botanical medicines that have been efficaciously employed in the likes of traditional medicine doctrines for millennium. Integral to this approach is the necessity of neuritogenesis and/or neuroprotection to counterbalance the deleterious effects of amyloid-β (Aβ) proteins. Senegenin, a principle saponin of Polygala tenuifolia Willd., which has empirically shown to improve cognition and intelligence, was chosen to evaluate its cytoprotective potential and possible neuritogenic and neuroprotective effects.