Up-Regulation of CCT8 Related to Neuronal Apoptosis after Traumatic Brain Injury in Adult Rats

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• 作者：Xiaohong Wu ; Haiyan Zhang ; Dongjian Chen ; Yan Song ; Rong Qian…
• 关键词：Traumatic brain injury ; Neuronal apoptosis ; CCT8
• 刊名：Neurochemical Research
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：40
• 期：9
• 页码：1882-1891
• 全文大小：4,410 KB
• 参考文献：1.Andelic N (2013) The epidemiology of traumatic brain injury. Lancet Neurol 12:28鈥?9CrossRef PubMed
  2.Faden AI (2002) Neuroprotection and traumatic brain injury: theoretical option or realistic proposition. Curr Opin Neurol 15:707鈥?12CrossRef PubMed
  3.Ansari MA, Roberts KN, Scheff SW (2008) Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury. Free Radic Biol Med 45:443鈥?52PubMed Central CrossRef PubMed
  4.Xiong Y, Mahmood A, Chopp M (2009) Emerging treatments for traumatic brain injury. Expert Opin Emerg Drugs 14:67鈥?4PubMed Central CrossRef PubMed
  5.Okano HJ, Pfaff DW, Gibbs RB (1993) RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis. J Neurosci 13:2930鈥?938PubMed
  6.Di Giovanni S, Movsesyan V, Ahmed F, Cernak I, Schinelli S, Stoica B, Faden AI (2005) Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury. Proc Natl Acad Sci USA 102:8333鈥?338PubMed Central CrossRef PubMed
  7.Nguyen MD, Mushynski WE, Julien JP (2002) Cycling at the interface between neurodevelopment and neurodegeneration. Cell Death Differ 9:1294鈥?306CrossRef PubMed
  8.Wartiovaara K, Barnabe-Heider F, Miller FD, Kaplan DR (2002) N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons. J Neurosci 22:815鈥?24PubMed
  9.Leroux MR, Hartl FU (2000) Protein folding: versatility of the cytosolic chaperonin TRiC/CCT. Curr Biol: CB 10:R260鈥揜264CrossRef PubMed
  10.Melki R (2001) Review: nucleotide-dependent conformational changes of the chaperonin containing TCP-1. J Struct Biol 135:170鈥?75CrossRef PubMed
  11.Kubota H, Hynes G, Carne A, Ashworth A, Willison K (1994) Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin. Curr Biol: CB 4:89鈥?9CrossRef PubMed
  12.Kubota H, Hynes G, Willison K (1995) The eighth Cct gene, Cctq, encoding the theta subunit of the cytosolic chaperonin containing TCP-1. Gene 154:231鈥?36CrossRef PubMed
  13.Kubota H, Hynes GM, Kerr SM, Willison KR (1997) Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1. FEBS Lett 402:53鈥?6CrossRef PubMed
  14.Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI (1998) Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. Mol Cell Biol 18:7584鈥?589PubMed Central PubMed
  15.Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA (2002) Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. Genes Dev 16:3130鈥?135PubMed Central CrossRef PubMed
  16.Siegers K, Bolter B, Schwarz JP, Bottcher UM, Guha S, Hartl FU (2008) TRiC/CCT cooperates with different upstream chaperones in the folding of distinct protein classes. EMBO J 27:301PubMed Central CrossRef PubMed
  17.Frydman J, Hartl FU (1996) Principles of chaperone-assisted protein folding: differences between in vitro and in vivo mechanisms. Science 272:1497鈥?502CrossRef PubMed
  18.Farr GW, Scharl EC, Schumacher RJ, Sondek S, Horwich AL (1997) Chaperonin-mediated folding in the eukaryotic cytosol proceeds through rounds of release of native and nonnative forms. Cell 89:927鈥?37CrossRef PubMed
  19.Srikakulam R, Winkelmann DA (1999) Myosin II folding is mediated by a molecular chaperonin. J Biol Chem 274:27265鈥?7273CrossRef PubMed
  20.Feldman DE, Thulasiraman V, Ferreyra RG, Frydman J (1999) Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC. Mol Cell 4:1051鈥?061CrossRef PubMed
  21.Gebauer M, Melki R, Gehring U (1998) The chaperone cofactor Hop/p60 interacts with the cytosolic chaperonin-containing TCP-1 and affects its nucleotide exchange and protein folding activities. J Biol Chem 273:29475鈥?9480CrossRef PubMed
  22.Brackley KI, Grantham J (2009) Activities of the chaperonin containing TCP-1 (CCT): implications for cell cycle progression and cytoskeletal organisation. Cell Stress Chaperones 14:23鈥?1PubMed Central CrossRef PubMed
  23.Yokota S, Yanagi H, Yura T, Kubota H (1999) Cytosolic chaperonin is up-regulated during cell growth. Preferential expression and binding to tubulin at G(1)/S transition through early S phase. J Biol Chem 274:37070鈥?7078CrossRef PubMed
  24.Yokota S, Yamamoto Y, Shimizu K, Momoi H, Kamikawa T, Yamaoka Y, Yanagi H, Yura T, Kubota H (2001) Increased expression of cytosolic chaperonin CCT in human hepatocellular and colonic carcinoma. Cell Stress Chaperones 6:345鈥?50PubMed Central CrossRef PubMed
  25.Grantham J, Brackley KI, Willison KR (2006) Substantial CCT activity is required for cell cycle progression and cytoskeletal organization in mammalian cells. Exp Cell Res 312:2309鈥?324CrossRef PubMed
  26.Shaw PG, Chaerkady R, Wang T, Vasilatos S, Huang Y, Van Houten B, Pandey A, Davidson NE (2013) Integrated proteomic and metabolic analysis of breast cancer progression. PLoS One 8:e76220PubMed Central CrossRef PubMed
  27.Seiden-Long IM, Brown KR, Shih W, Wigle DA, Radulovich N, Jurisica I, Tsao MS (2006) Transcriptional targets of hepatocyte growth factor signaling and Ki-ras oncogene activation in colorectal cancer. Oncogene 25:91鈥?02PubMed
  28.Liu Y, Wang Y, Cheng C, Chen Y, Shi S, Qin J, Xiao F, Zhou D, Lu M, Lu Q, Shen A (2010) A relationship between p27(kip1) and Skp2 after adult brain injury: implications for glial proliferation. J Neurotrauma 27:361鈥?71CrossRef PubMed
  29.Logan A, Frautschy SA, Gonzalez AM, Baird A (1992) A time course for the focal elevation of synthesis of basic fibroblast growth factor and one of its high-affinity receptors (flg) following a localized cortical brain injury. J Neurosci 12:3828鈥?837PubMed Central PubMed
  30.Zhang H, Liu Y, Li Y, Zhou Y, Chen D, Shen J, Yan Y, Yan S, Wu X, Li A, Guo A, Cheng C (2014) The expression of CAP1 after traumatic brain injury and its role in astrocyte proliferation. J Mol Neurosci 54:653鈥?63CrossRef PubMed
  31.Becker EB, Bonni A (2004) Cell cycle regulation of neuronal apoptosis in development and disease. Prog Neurobiol 72:1鈥?5CrossRef PubMed
  32.Stoica BA, Byrnes KR, Faden AI (2009) Cell cycle activation and CNS injury. Neurotox Res 16:221鈥?37CrossRef PubMed
  33.Slemmer JE, Zhu C, Landshamer S, Trabold R, Grohm J, Ardeshiri A, Wagner E, Sweeney MI, Blomgren K, Culmsee C, Weber JT, Plesnila N (2008) Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury. Am J Pathol 173:1795鈥?805PubMed Central CrossRef PubMed
  34.Cernak I, Stoica B, Byrnes KR, Di Giovanni S, Faden AI (2005) Role of the cell cycle in the pathobiology of central nervous system trauma. Cell Cycle 4:1286鈥?293CrossRef PubMed
  35.Di Giovanni S, Knoblach SM, Brandoli C, Aden SA, Hoffman EP, Faden AI (2003) Gene profiling in spinal cord injury shows role of cell cycle in neuronal death. Ann Neurol 53:454鈥?68CrossRef PubMed
  36.Shuman SL, Bresnahan JC, Beattie MS (1997) Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats. J Neurosci Res 50:798鈥?08CrossRef PubMed
  37.Grossman SD, Rosenberg LJ, Wrathall JR (2001) Temporal-spatial pattern of acute neuronal and glial loss after spinal cord contusion. Exp Neurol 168:273鈥?82CrossRef PubMed
  38.Beattie MS, Harrington AW, Lee R, Kim JY, Boyce SL, Longo FM, Bresnahan JC, Hempstead BL, Yoon SO (2002) ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron 36:375鈥?86PubMed Central CrossRef PubMed
  39.McBride CB, McPhail LT, Vanderluit JL, Tetzlaff W, Steeves JD (2003) Caspase inhibition attenuates transection-induced oligodendrocyte apoptosis in the developing chick spinal cord. Mol Cell Neurosci 23:383鈥?97CrossRef PubMed
  40.Stirling DP, Khodarahmi K, Liu J, McPhail LT, McBride CB, Steeves JD, Ramer MS, Tetzlaff W (2004) Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury. J Neurosci 24:2182鈥?190CrossRef PubMed
  41.Knoblach SM, Huang X, VanGelderen J, Calva-Cerqueira D, Faden AI (2005) Selective caspase activation may contribute to neurological dysfunction after experimental spinal cord trauma. J Neurosci Res 80:369鈥?80CrossRef PubMed
  42.Herrup K, Busser JC (1995) The induction of multiple cell cycle events precedes target-related neuronal death. Development 121:2385鈥?395PubMed
  43.Ikeda Y, Matsunaga Y, Takiguchi M, Ikeda MA (2011) Expression of cyclin E in postmitotic neurons during development and in the adult mouse brain. Gene Expr Patterns 11:64鈥?1CrossRef PubMed
  44.Chen B, Wang W (2008) The expression of cyclins in neurons of rats after focal cerebral ischemia. Journal of Huazhong University of Science and Technology Medical sciences聽=聽Hua zhong ke ji da xue xue bao Yi xue Ying De wen ban聽=聽Huazhong keji daxue xuebao Yixue Yingdewen ban 28:60-64
  45.Kubota H, Hynes G, Willison K (1995) The chaperonin containing t-complex polypeptide 1 (TCP-1). Multisubunit machinery assisting in protein folding and assembly in the eukaryotic cytosol. Eur J Biochem/FEBS 230:3鈥?6CrossRef
  46.Willison KR, Hynes G, Davies P, Goldsborough A, Lewis VA (1990) Expression of three t-complex genes, Tcp-1, D17Leh117c3, and D17Leh66, in purified murine spermatogenic cell populations. Genet Res 56:193鈥?01CrossRef PubMed
  47.Kubota H, Willison K, Ashworth A, Nozaki M, Miyamoto H, Yamamoto H, Matsushiro A, Morita T (1992) Structure and expression of the gene encoding mouse t-complex polypeptide (Tcp-1). Gene 120:207鈥?15CrossRef PubMed
  48.Huang X, Wang X, Cheng C, Cai J, He S, Wang H, Liu F, Zhu C, Ding Z, Huang X, Zhang T, Zhang Y (2014) Chaperonin containing TCP1, subunit 8 (CCT8) is upregulated in hepatocellular carcinoma and promotes HCC proliferation. Acta Pathol Microbiol Immunol Scand 122:1070鈥?079
  
• 作者单位：Xiaohong Wu (1)
  Haiyan Zhang (2)
  Dongjian Chen (2) (3)
  Yan Song (2) (4)
  Rong Qian (2) (5)
  Chen Chen (2) (5)
  Xingxing Mao (2) (5)
  Xinlei Chen (2) (5)
  Weidong Zhang (2) (5)
  Bai Shao (1)
  Jianhong Shen (3)
  Yaohua Yan (3)
  Xinmin Wu (3)
  Yonghua Liu (2) (6)
  
  1. Department of Neurosurgery, Dongtai People Affiliated Hospital of Nantong University, Yancheng, 224200, Jiangsu Province, People鈥檚 Republic of China
  2. Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, 226001, Jiangsu Province, People鈥檚 Republic of China
  3. Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, People鈥檚 Republic of China
  4. Department of Neurology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, People鈥檚 Republic of China
  5. Department of Orthopaedic, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, People鈥檚 Republic of China
  6. Department of Pathogen Biology, Medical College of Nantong University, Nantong, 226001, Jiangsu Province, People鈥檚 Republic of China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Biochemistry
  Neurology
  
• 出版者：Springer Netherlands
• ISSN：1573-6903

文摘

Traumatic brain injury (TBI) initiates a series of neurochemical and signaling changes that could eventually lead to neuronal apoptosis. Recent studies indicated that mature neurons cell cycle re-enter played a crucial role in neuronal apoptosis. In this study, we identified that the chaperonin containing TCP-1, subunit 8 (CCT8), as a member of class II chaperonins, was significantly upregulated following TBI. Moreover, double immunofluorescence staining revealed that CCT8 was co-expressed with neuronal nuclei (NeuN). Besides, co-localization of CCT8/active caspase 3 was detected in NeuN. We also examined the expression profiles of active caspase 3 whose changes were correlated with the expression of CCT8. All our findings suggested that CCT8 might be involved in the pathophysiology of brain after TBI. Keywords Traumatic brain injury Neuronal apoptosis CCT8