The functional sites of miRNAs and lncRNAs in gastric carcinogenesis
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  • 作者：Xiangxiang Wan (1)
    Xiaoyun Ding (1)
    Shengcan Chen (2)
    Haojun Song (1)
    Haizhong Jiang (1)
    Ying Fang (1)
    Peifei Li (2)
    Junming Guo (2)

    1. Department of Gastroenterology     ; Ningbo First Hospital ; No. 59 Liuting Street ; Ningbo ; 315010 ; China
    2. Department of Biochemistry and Molecular Biology     ; Zhejiang Provincial Key Laboratory of Pathophysiology ; Ningbo University School of Medicine ; Ningbo ; 315211 ; China
  • 关键词：miRNAs ; lncRNAs ; Gastric carcinogenesis ; Mechanisms
  • 刊名：Tumor Biology
  • 出版年：2015
  • 出版时间：February 2015
  • 年：2015
  • 卷：36
  • 期：2
  • 页码：521-532
  • 全文大小：1,765 KB
  • 参考文献：1. Piazuelo, MB, Correa, P (2013) Gastric cancer: overview. Colomb Med (Cali, Colombia) 44: pp. 192-201
    2. Song, JH, Meltzer, SJ (2012) MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers. Gastroenterology 143: pp. 35-47 e32 CrossRef
    3. Esteller, M (2011) Non-coding RNAs in human disease. Nat Rev Genet 12: pp. 861-74 CrossRef
    4. Wu, HH, Lin, WC, Tsai, KW (2014) Advances in molecular biomarkers for gastric cancer: MiRNAs as emerging novel cancer markers. Expert Rev Mol Med 16: pp. e1 CrossRef
    5. Li, X, Wu, Z, Fu, X, Han, W (2013) Long non-coding RNAs: insights from biological features and functions to diseases. Med Res Rev 33: pp. 517-53 CrossRef
    6. Li, P-F (2014) Non-coding RNAs and gastric cancer. World J Gastroenterol 20: pp. 5411 CrossRef
    7. Noatynska, A, Tavernier, N, Gotta, M, Pintard, L (2013) Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms?. Open Biol 3: pp. 130083 CrossRef
    8. Hindley, C, Philpott, A (2013) The cell cycle and pluripotency. Biochem J 451: pp. 135-43 CrossRef
    9. Kapinas, K, Grandy, R, Ghule, P, Medina, R, Becker, K, Pardee, A (2013) The abbreviated pluripotent cell cycle. J Cell Physiol 228: pp. 9-20 CrossRef
    10. Xia, J, Wu, Z, Yu, C, He, W, Zheng, H, He, Y (2012) Mir-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1. J Pathol 227: pp. 470-80 CrossRef
    11. Guo, SL, Ye, H, Teng, Y, Wang, YL, Yang, G, Li, XB (2013) Akt-p53-miR-365-Cyclin D1/cdc25A axis contributes to gastric tumorigenesis induced by PTEN deficiency. Nat Commun 4: pp. 2544
    12. Zhang, BG, Li, JF, Yu, BQ, Zhu, ZG, Liu, BY, Yan, M (2012) MicroRNA-21 promotes tumor proliferation and invasion in gastric cancer by targeting PTEN. Oncol Rep 27: pp. 1019-26
    13. Namba, H, Saenko, V, Yamashita, S (2007) Nuclear factor-kB in thyroid carcinogenesis and progression: a novel therapeutic target for advanced thyroid cancer. Arq Bras Endocrinol Metabologia 51: pp. 843-51 CrossRef
    14. Tu, H, Sun, H, Lin, Y, Ding, J, Nan, K, Li, Z (2014) Oxidative stress upregulates PDCD4 expression in patients with gastric cancer via miR-21. Curr Pharm Des 20: pp. 1917-23 CrossRef
    15. Shin, VY, Jin, H, Ng, EK, Cheng, AS, Chong, WW, Wong, CY (2011) NF-魏B targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin e receptors. Carcinogenesis 32: pp. 240-5 CrossRef
    16. Xia, JT, Chen, LZ, Jian, WH, Wang, KB, Yang, YZ, He, WL (2014) MicroRNA-362 induces cell proliferation and apoptosis resistance in gastric cancer by activation of NF-魏B signaling. J Transl Med 12: pp. 33 CrossRef
    17. Sheng, S, Qiao, M, Pardee, AB (2009) Metastasis and Akt activation. J Cell Physiol 218: pp. 451-4 CrossRef
    18. Nishida, N, Mimori, K, Fabbri, M, Yokobori, T, Sudo, T, Tanaka, F (2011) MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. Clin Cancer Res Off J Am Assoc Cancer Res 17: pp. 2725-33 CrossRef
    19. Peng, Y, Liu, YM, Li, LC, Wang, LL, Wu, XL (2014) MicroRNA-338 inhibits growth, invasion and metastasis of gastric cancer by targeting NRP1 expression. PLoS ONE 9: pp. e94422 CrossRef
    20. Yang, Q, Jie, Z, Cao, H, Greenlee, AR, Yang, C, Zou, F (2011) Low-level expression of let-7a in gastric cancer and its involvement in tumorigenesis by targeting RAB40C. Carcinogenesis 32: pp. 713-22 CrossRef
    21. Liu, XH, Sun, M, Nie, FQ, Ge, YB, Zhang, EB, Yin, DD (2014) Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Mol Cancer 13: pp. 92 CrossRef
    22. Sukawa, Y, Yamamoto, H, Nosho, K, Ito, M, Igarashi, H, Naito, T (2014) HER2 expression and PI3K-Akt pathway alterations in gastric cancer. Digestion 89: pp. 12-7 CrossRef
    23. Li, F, Liu, B, Gao, Y, Liu, Y, Xu, Y, Tong, W (2014) Upregulation of microRNA-107 induces proliferation in human gastric cancer cells by targeting the transcription factor FOXO1. FEBS Lett 588: pp. 538-44 CrossRef
    24. Feng, L, Xie, Y, Zhang, H, Wu, Y (2012) miR-107 targets Cyclin-dependent kinase 6 expression, induces cell cycle G1 arrest and inhibits invasion in gastric cancer cells. Med Oncol 29: pp. 856-63 CrossRef
    25. Feng, Y, Wang, L, Zeng, J, Shen, L, Liang, X, Yu, H (2013) FoxM1 is overexpressed in helicobacter pylori-induced gastric carcinogenesis and is negatively regulated by miR-370. Mol Cancer Res MCR 11: pp. 834-44 CrossRef
    26. Bou Kheir, T, Futoma-Kazmierczak, E, Jacobsen, A, Krogh, A, Bardram, L, Hother, C (2011) Mir-449 inhibits cell proliferation and is down-regulated in gastric cancer. Mol Cancer 10: pp. 29 CrossRef
    27. Zhang, X, Zhu, W, Zhang, J, Huo, S, Zhou, L, Gu, Z (2010) MicroRNA-650 targets ING4 to promote gastric cancer tumorigenicity. Biochem Biophys Res Commun 395: pp. 275-80 CrossRef
    28. Zhang X, Nie Y, Li X, Wu G, Huang Q, Cao J, Du Y, Li J, Deng R, Huang D, Chen B, Li S, Wei B: Microrna-181a functions as an oncomir in gastric cancer by targeting the tumour suppressor gene atm. Pathology oncology research : POR 2014.
    29. Kubota, E, Williamson, CT, Ye, R, Elegbede, A, Peterson, L, Lees-Miller, SP, Bebb, DG (2014) Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. Cell Cycle (Georgetown, Tex) 13: pp. 2129-37 CrossRef
    30. Wang, M, Gu, H, Qian, H, Zhu, W, Zhao, C, Zhang, X (2013) miR-17-5p/20a are important markers for gastric cancer and murine double minute 2 participates in their functional regulation. Eur J Cancer 49: pp. 2010-21 CrossRef
    31. Ai, YW, Yu, HG, Yu, JP, Yang, Y, Li, H, Hu, XW, Luo, HS (2008) [Impact of PI3K/Akt /mdm2 signaling pathway on the sensitivity of gastric cancer cell line SGC7901 to doxorubicin] [Article in Chinese]. Zhonghua Zhong Liu Za Zhi [Chin J Oncol] 30: pp. 494-97
    32. Zhang, EB, Han, L, Yin, DD, Kong, R, De, W, Chen, J (2014) C-Myc-induced, long, noncoding H19 affects cell proliferation and predicts a poor prognosis in patients with gastric cancer. Med Oncol 31: pp. 914 CrossRef
    33. Yang, F, Xue, X, Bi, J, Zheng, L, Zhi, K, Gu, Y (2013) Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma. J Cancer Res Clin Oncol 139: pp. 437-45 CrossRef
    34. Yang, F, Bi, J, Xue, X, Zheng, L, Zhi, K, Hua, J (2012) Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells. FEBS J 279: pp. 3159-65 CrossRef
    35. Zhuang, M, Gao, W, Xu, J, Wang, P, Shu, Y (2014) The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1. Biochem Biophys Res Commun 448: pp. 315-22 CrossRef
    36. Sun, M, Liu, XH, Li, JH, Yang, JS, Zhang, EB, Yin, DD (2012) miR-196a is upregulated in gastric cancer and promotes cell proliferation by downregulating p27(kip1). Mol Cancer Ther 11: pp. 842-52 CrossRef
    37. Sun, M, Jin, FY, Xia, R, Kong, R, Li, JH, Xu, TP (2014) Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer. BMC Cancer 14: pp. 319 CrossRef
    38. Jiping, Z, Ming, F, Lixiang, W, Xiuming, L, Yuqun, S, Han, Y (2013) MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2. J Cell Biochem 114: pp. 2666-72 CrossRef
    39. Tang, H, Deng, M, Tang, Y, Xie, X, Guo, J, Kong, Y (2013) miR-200b and miR-200c as prognostic factors and mediators of gastric cancer cell progression. Clin Cancer Res Offl J Am Assoc Cancer Res 19: pp. 5602-12 CrossRef
    40. Zhang, EB, Kong, R, Yin, DD, You, LH, Sun, M, Han, L (2014) Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a. Oncotarget 5: pp. 2276-92
    41. Gong, J, Li, J, Wang, Y, Liu, C, Jia, H, Jiang, C (2014) Characterization of microRNA-29 family expression and investigation of their mechanistic roles in gastric cancer. Carcinogenesis 35: pp. 497-506 CrossRef
    42. Zhang, L, Liu, X, Jin, H, Guo, X, Xia, L, Chen, Z (2013) miR-206 inhibits gastric cancer proliferation in part by repressing Cyclin D2. Cancer Lett 332: pp. 94-101 CrossRef
    43. Deng, Y, Huang, Z, Xu, Y, Jin, J, Zhuo, W, Zhang, C (2014) miR-215 modulates gastric cancer cell proliferation by targeting RB1. Cancer Lett 342: pp. 27-35 CrossRef
    44. Liu, T, Tang, H, Lang, Y, Liu, M, Li, X (2009) MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin. Cancer Lett 273: pp. 233-42 CrossRef
    45. Qiu, T, Zhou, X, Wang, J, Du, Y, Xu, J, Huang, Z (2014) miR-145, miR-133A and miR-133b inhibit proliferation, migration, invasion and cell cycle progression via targeting transcription factor Sp1 in gastric cancer. FEBS Lett 588: pp. 1168-77 CrossRef
    46. Zhao, LY, Yao, Y, Han, J, Yang, J, Wang, XF, Tong, DD (2014) miR-638 suppresses cell proliferation in gastric cancer by targeting Sp2. Dig Dis Sci 59: pp. 1743-53 CrossRef
    47. Xu, Y, Zhao, F, Wang, Z, Song, Y, Luo, Y, Zhang, X (2012) MicroRNA-335 acts as a metastasis suppressor in gastric cancer by targeting Bcl-w and specificity protein 1. Oncogene 31: pp. 1398-407 CrossRef
    48. Tsai, KW, Liao, YL, Wu, CW, Hu, LY, Li, SC, Chan, WC (2011) Aberrant hypermethylation of miR-9 genes in gastric cancer. Epigenetics: Off J DNA Methylation 6: pp. 1189-97 CrossRef
    49. Zheng, L, Qi, T, Yang, D, Qi, M, Li, D, Xiang, X (2013) MicroRNA-9 suppresses the proliferation, invasion and metastasis of gastric cancer cells through targeting Cyclin D1 and Ets1. PLoS ONE 8: pp. e55719 CrossRef
    50. Deng, H, Guo, Y, Song, H, Xiao, B, Sun, W, Liu, Z (2013) MicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigenetical regulation in gastric cancer. Gene 518: pp. 351-9 CrossRef
    51. Gandarillas, A (2012) The mysterious human epidermal cell cycle, or an oncogene-induced differentiation checkpoint. Cell Cycle (Georgetown, Tex) 11: pp. 4507-16 CrossRef
    52. Schmidt, EV (2004) The role of c-Myc in regulation of translation initiation. Oncogene 23: pp. 3217-21 CrossRef
    53. Zhou, W, Marcus, AI, Vertino, PM (2013) Dysregulation of mTOR activity through LKB1 inactivation. Chinese J cancer 32: pp. 427-33 CrossRef
    54. Li, W, Jin, X, Deng, X, Zhang, G, Zhang, B, Ma, L (2014) The putative tumor suppressor microRNA-497 modulates gastric cancer cell proliferation and invasion by repressing eIf4E. Biochem Biophys Res Commun 449: pp. 235-40 CrossRef
    55. Peng, W, Chen, ZY, Wang, L, Wang, Z, Li, J (2013) MicroRNA-199a-3p is downregulated in gastric carcinomas and modulates cell proliferation. Genet Mol Res GMR 12: pp. 3038-47 CrossRef
    56. Wu, W, Takanashi, M, Borjigin, N, Ohno, SI, Fujita, K, Hoshino, S (2013) MicroRNA-18a modulates STAT3 activity through negative regulation of PIAS3 during gastric adenocarcinogenesis. Br J Cancer 108: pp. 653-61 CrossRef
    57. Qin, S, Ai, F, Ji, W-F, Rao, W, Zhang, H-C, Yao, W-J (2013) miR-19a promotes cell growth and tumorigenesis through targeting SOCS1 in gastric cancer. Asian Pac J Cancer Prev 14: pp. 835-40 CrossRef
    58. Ding, L, Xu, Y, Zhang, W, Deng, Y, Si, M, Du, Y (2010) miR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2. Cell Res 20: pp. 784-93 CrossRef
    59. Wu, Q, Yang, Z, An, Y, Hu, H, Yin, J, Zhang, P (2014) miR-19a/b modulate the metastasis of gastric cancer cells by targeting the tumour suppressor MXD1. Cell Death Dis 5: pp. e1144 CrossRef
    60. Hsu, KW, Wang, AM, Ping, YH, Huang, KH, Huang, TT, Lee, HC (2014) Downregulation of tumor suppressor MBP-1 by microRNA-363 in gastric carcinogenesis. Carcinogenesis 35: pp. 208-17 CrossRef
    61. Sun, T, Wang, C, Xing, J, Wu, D (2011) miR-429 modulates the expression of c-Myc in human gastric carcinoma cells. Eur J Cancer 47: pp. 2552-9 CrossRef
    62. He, W, Li, Y, Chen, X, Lu, L, Tang, B, Wang, Z (2014) miR-494 acts as an anti-oncogene in gastric carcinoma by targeting c-Myc. J Gastroenterol Hepatol 29: pp. 1427-34 CrossRef
    63. Yang, F, Xue, X, Zheng, L, Bi, J, Zhou, Y, Zhi, K (2014) Long non-coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c-Myc mRNA stability. FEBS J 281: pp. 802-13 CrossRef
    64. Gao, J, Senthil, M, Ren, B, Yan, J, Xing, Q, Yu, J (2010) IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells. Cell Death Differ 17: pp. 699-709 CrossRef
    65. Yang, SJ, Meng, JP, Qu, Y, Liu, YB (2007) The progress on the signal transduction pathways of apoptosis. Chin J Com Med 17: pp. 297-301
    66. Sacconi, A, Biagioni, F, Canu, V, Mori, F, Benedetto, A, Lorenzon, L (2012) miR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancer. Cell Death Dis 3: pp. e423 CrossRef
    67. Wei, B, Song, Y, Zhang, Y, Hu, M (2013) MicroRNA-449a functions as a tumor-suppressor in gastric adenocarcinoma by targeting Bcl-2. Oncol Lett 6: pp. 1713-8
    68. He, XP, Shao, Y, Li, XL, Xu, W, Chen, GS, Sun, HH (2012) Downregulation of miR-101 in gastric cancer correlates with cyclooxygenase-2 overexpression and tumor growth. FEBS J 279: pp. 4201-12 CrossRef
    69. Gao, C, Zhang, Z, Liu, W, Xiao, S, Gu, W, Lu, H (2010) Reduced microRNA-218 expression is associated with high nuclear factor kappa B activation in gastric cancer. Cancer 116: pp. 41-9 CrossRef
    70. Zhao, Y, Li, C, Wang, M, Su, L, Qu, Y, Li, J (2013) Decrease of miR-202-3p expression, a novel tumor suppressor, in gastric cancer. PLoS ONE 8: pp. e69756 CrossRef
    71. Liu, X, Ru, J, Zhang, J, Zhu, LH, Liu, M, Li, X (2013) miR-23a targets interferon regulatory factor 1 and modulates cellular proliferation and paclitaxel-induced apoptosis in gastric adenocarcinoma cells. PLoS ONE 8: pp. e64707 CrossRef
    72. Saito, Y, Suzuki, H, Imaeda, H, Matsuzaki, J, Hirata, K, Tsugawa, H (2013) The tumor suppressor microRNA-29c is downregulated and restored by celecoxib in human gastric cancer cells. Int J Cancer 132: pp. 1751-60 CrossRef
    73. Noto, JM, Piazuelo, MB, Chaturvedi, R, Bartel, CA, Thatcher, EJ, Delgado, A (2013) Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the anti-apoptotic protein Mcl-1. Am J Physiol Gastrointest Liver Physiol 305: pp. G786-96 CrossRef
    74. Wang, Z, Liu, M, Zhu, H, Zhang, W, He, S, Hu, C (2013) miR-106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS. Mol Carcinog 52: pp. 634-46 CrossRef
    75. Tsukamoto, Y, Nakada, C, Noguchi, T, Tanigawa, M, Nguyen, LT, Uchida, T (2010) MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3 zeta. Cancer Res 70: pp. 2339-49 CrossRef
    76. Li, C, Nie, H, Wang, M, Su, L, Li, J, Yu, B (2012) MicroRNA-409-3p regulates cell proliferation and apoptosis by targeting PHF10 in gastric cancer. Cancer Lett 320: pp. 189-97 CrossRef
    77. Li, YH, Chen, M, Zhang, M, Zhang, XQ, Zhang, S, Yu, CG (2014) Inhibitory effect of survivin-targeting small interfering RNA on gastric cancer cells. Genetics Mol Re : GMR 13: pp. 6786-803 CrossRef
    78. Zhao, Y, Guo, Q, Chen, J, Hu, J, Wang, S, Sun, Y (2014) Role of long non-coding RNA HULC in cell proliferation, apoptosis and tumor metastasis of gastric cancer: a clinical and in vitro investigation. Oncol Rep 31: pp. 358-64
    79. Hanahan, D, Weinberg, RA (2011) Hallmarks of cancer: the next generation. Cell 144: pp. 646-74 CrossRef
    80. Ijaz, T, Pazdrak, K, Kalita, M, Konig, R, Choudhary, S, Tian, B (2014) Systems biology approaches to understanding epithelial mesenchymal transition (EMT) in mucosal remodeling and signaling in asthma. World Allergy Organ J 7: pp. 13 CrossRef
    81. Diaz-Lopez, A, Moreno-Bueno, G, Cano, A (2014) Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives. Cancer Manag Res 6: pp. 205-16
    82. Pencheva, N, Tavazoie, SF (2013) Control of metastatic progression by microRNA regulatory networks. Nat Cell Biol 15: pp. 546-54 CrossRef
    83. Kogo, R, Mimori, K, Tanaka, F, Komune, S, Mori, M (2011) Clinical significance of miR-146a in gastric cancer cases. Clin Cancer Res Off J Am Assoc Cancer Res 17: pp. 4277-84 CrossRef
    84. Xie, J, Chen, M, Zhou, J, Mo, MS, Zhu, LH, Liu, YP (2014) miR-7 inhibits the invasion and metastasis of gastric cancer cells by suppressing epidermal growth factor receptor expression. Oncol Rep 31: pp. 1715-22
    85. Zhao, X, Dou, W, He, L, Liang, S, Tie, J, Liu, C (2013) MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor 1 receptor. Oncogene 32: pp. 1363-72 CrossRef
    86. Deng, M, Tang, HL, Lu, XH, Liu, MY, Lu, XM, Gu, YX (2013) miR-26a suppresses tumor growth and metastasis by targeting FGF9 in gastric cancer. PLoS ONE 8: pp. e72662 CrossRef
    87. Peng Y, Guo JJ, Liu YM, Wu XL. MicroRNA-34a inhibits the growth, invasion and metastasis of gastric cancer by targeting PDGFR and MET expression. Bioscience reports 2014; 34
    88. Lo, SS, Hung, PS, Chen, JH, Tu, HF, Fang, WL, Chen, CY (2012) Overexpression of miR-370 and downregulation of its novel target TGF尾-RII contribute to the progression of gastric carcinoma. Oncogene 31: pp. 226-37 CrossRef
    89. Li, CL, Nie, H, Wang, M, Su, LP, Li, JF, Yu, YY (2012) MicroRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis. Oncol Rep 27: pp. 1960-6
    90. Liu, XJ, Chen, ZF, Li, HL, Hu, ZN, Liu, M, Tian, AP (2013) Interaction between cyclooxygenase-2, Snail, and E-cadherin in gastric cancer cells. World J Gastroenterol WJG 19: pp. 6265-71 CrossRef
    91. Jia, L, Wu, J, Zhang, L, Chen, J, Zhong, D, Xu, S (2013) Restoration of miR-1228* expression suppresses epithelial-mesenchymal transition in gastric cancer. PLoS ONE 8: pp. e58637 CrossRef
    92. Carvalho, J, Grieken, NC, Pereira, PM, Sousa, S, Tijssen, M, Buffart, TE (2012) Lack of microRNA-101 causes E-cadherin functional deregulation through EZH2 up-regulation in intestinal gastric cancer. J Pathol 228: pp. 31-44
    93. Liao, YL, Hu, LY, Tsai, KW, Wu, CW, Chan, WC, Li, SC (2012) Transcriptional regulation of miR-196b by ETS2 in gastric cancer cells. Carcinogenesis 33: pp. 760-9 CrossRef
    94. Song, F, Yang, D, Liu, B, Guo, Y, Zheng, H, Li, L (2014) Integrated microRNA network analyses identify a poor-prognosis subtype of gastric cancer characterized by the miR-200 family. Clin Cancer Res Off J Am Assoc Cancer Res 20: pp. 878-89 CrossRef
    95. Shin, JY, Kim, YI, Cho, SJ, Lee, MK, Kook, MC, Lee, JH (2014) MicroRNA-135a suppresses lymph node metastasis through down-regulation of ROCK1 in early gastric cancer. PLoS ONE 9: pp. e85205 CrossRef
    96. Song, Y, Zhao, F, Wang, Z, Liu, Z, Chiang, Y, Xu, Y (2012) Inverse association between miR-194 expression and tumor invasion in gastric cancer. Ann Surg Oncol 19: pp. S509-17 CrossRef
    97. Zhou, L, Zhao, X, Han, Y, Lu, Y, Shang, Y, Liu, C (2013) Regulation of UHRF1 by miR-146a/b modulates gastric cancer invasion and metastasis. FASEB J Off Publ Fed Am Soc Exp Biology 27: pp. 4929-39
    98. Jin, Z, Selaru, FM, Cheng, Y, Kan, T, Agarwal, R, Mori, Y (2011) MicroRNA-192 and -215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro. Oncogene 30: pp. 1577-85 CrossRef
    99. Xu, ZY, Yu, QM, Du, YA, Yang, LT, Dong, RZ, Huang, L (2013) Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial-mesenchymal transition in gastric cancer. Int J Biol Sci 9: pp. 587-97 CrossRef
    100. Ruth, MC, Xu, Y, Maxwell, IH, Ahn, NG, Norris, DA, Shellman, YG (2006) RhoC promotes human melanoma invasion in a PI3K/Akt-dependent pathway. J Investig Dermatol 126: pp. 862-8 CrossRef
    101. Rath, N, Olson, MF (2012) Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy. EMBO Rep 13: pp. 900-8 CrossRef
    102. Zheng, B, Liang, L, Wang, C, Huang, S, Cao, X, Zha, R (2011) MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer. Clin Cancer Res Off J Am Assoc Cancer Res 17: pp. 7574-83 CrossRef
    103. Li, P, Chen, X, Su, L, Li, C, Zhi, Q, Yu, B (2013) Epigenetic silencing of miR-338-3p contributes to tumorigenicity in gastric cancer by targeting SSX2IP. PLoS ONE 8: pp. e66782 CrossRef
    104. Zuo, J, Xia, J, Ju, F, Yan, J, Zhu, A, Jin, S (2013) MicroRNA-148a can regulate runt-related transcription factor 3 gene expression via modulation of DNA methyltransferase 1 in gastric cancer. Mol Cells 35: pp. 313-9 CrossRef
    105. Qin, J, Wu, C (2012) ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling. Curr Opin Cell Biol 24: pp. 607-13 CrossRef
    106. Wang, M, Li, C, Nie, H, Lv, X, Qu, Y, Yu, B (2012) Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK. FEBS Lett 586: pp. 2382-8 CrossRef
    107. Han TS, Hur K, Xu G, Choi B, Okugawa Y, Toiyama Y, Oshima H, Oshima M, Lee HJ, Kim VN, Chang AN, Goel A, Yang HK. MicroRNA-29c mediates initiation of gastric carcinogenesis by directly targeting ITGB4. Gut 2014
    108. Wang, X, Yu, H, Lu, X, Zhang, P, Wang, M, Hu, Y (2014) miR-22 suppresses the proliferation and invasion of gastric cancer cells by inhibiting CD151. Biochem Biophys Res Commun 445: pp. 175-9 CrossRef
    109. Zhai R, Kan X, Wang B, Du H, Long Y, Wu H, Tao K, Wang G, Bao L, Li F, Zhang W. miR-152 suppresses gastric cancer cell proliferation and motility by targeting CD151. Tumour Biology: the journal of the International Society for Oncodevelopmental Biology and Medicine 2014.
    110. Liang, S, He, L, Zhao, X, Miao, Y, Gu, Y, Guo, C (2011) MicroRNA let-7f inhibits tumor invasion and metastasis by targeting MYH9 in human gastric cancer. PLoS ONE 6: pp. e18409 CrossRef
    111. Lukaszewicz-Zajac, M, Mroczko, B, Szmitkowski, M (2009) [The significance of metalloproteinases and their inhibitors in gastric cancer]. Postepy Hig Med Dosw (Online) 63: pp. 258-65
    112. Guo, MM, Hu, LH, Wang, YQ, Chen, P, Huang, JG, Lu, N (2013) miR-22 is down-regulated in gastric cancer, and its overexpression inhibits cell migration and invasion via targeting transcription factor Sp1. Med Oncol 30: pp. 542 CrossRef
    113. Gao, P, Xing, AY, Zhou, GY, Zhang, TG, Zhang, JP, Gao, C (2013) The molecular mechanism of microRNA-145 to suppress invasion-metastasis cascade in gastric cancer. Oncogene 32: pp. 491-501 CrossRef
    114. Zheng, L, Pu, J, Qi, T, Qi, M, Li, D, Xiang, X (2013) miRNA-145 targets v-ets erythroblastosis virus E26 oncogene homolog 1 to suppress the invasion, metastasis, and angiogenesis of gastric cancer cells. Mol Cancer Res MCR 11: pp. 182-93 CrossRef
    115. Zhu, M, Zhang, N, He, S, Lui, Y, Lu, G, Zhao, L (2014) MicroRNA-106a targets TIMP2 to regulate invasion and metastasis of gastric cancer. FEBS Lett 588: pp. 600-7 CrossRef
    116. Zhao, H, Wang, Y, Yang, L, Jiang, R, Li, W (2014) miR-25 promotes gastric cancer cells growth and motility by targeting RECK. Mol Cell Biochem 385: pp. 207-13 CrossRef
    117. Jiang, B, Li, Z, Zhang, W, Wang, H, Zhi, X, Feng, J (2014) miR-874 inhibits cell proliferation, migration and invasion through targeting aquaporin-3 in gastric cancer. J Gastroenterol 49: pp. 1011-25 CrossRef
    118. Sakamoto, N, Naito, Y, Oue, N, Sentani, K, Uraoka, N, Zarni Oo, H (2014) MicroRNA-148a is downregulated in gastric cancer, targets MMP7, and indicates tumor invasiveness and poor prognosis. Cancer Sci 105: pp. 236-43 CrossRef
    119. Chen H, Li L, Wang S, Lei Y, Ge Q, Lv N, Zhou X, Chen C. Reduced miR-126 expression facilitates angiogenesis of gastric cancer through its regulation on VEGF-A. Oncotarget 2014.
    120. Seok, JK, Lee, SH, Kim, MJ, Lee, YM (2014) MicroRNA-382 induced by HIF-1伪 is an angiogenic miR targeting the tumor suppressor phosphatase and tensin homolog. Nucleic Acids Res 42: pp. 8062-72 CrossRef
    121. Zheng, Y, Li, S, Ding, Y, Wang, Q, Luo, H, Shi, Q, Hao, Z, Xiao, G, Tong, S (2013) The role of miR-18a in gastric cancer angiogenesis. Hepatogastroenterology 60: pp. 1809-13
    122. Liu L, Yan B, Yang Z, Zhang X, Gu Q, Yue X. ncRuPAR inhibits gastric cancer progression by down-regulating protease-activated receptor-1. Tumour Biology : The Journal of the International Society for Oncodevelopmental Biology and Medicine 2014.
  • 刊物主题：Cancer Research;
  • 出版者：Springer Netherlands
  • ISSN：1423-0380
文摘
Gastric cancer is one of the most common malignant diseases and has one of the highest mortality rates worldwide. Its molecular mechanisms are poorly understood. Recently, the functions of non-coding RNAs (ncRNAs) in gastric cancer have attracted wide attention. Although the expression levels of various ncRNAs are different, they may work together in a network and contribute to gastric carcinogenesis by altering the expression of oncogenes or tumor suppressor genes. They affect the cell cycle, apoptosis, motility, invasion, and metastasis. Dysregulated microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), including miR-21, miR-106, H19, and ANRIL, directly or indirectly regulate carcinogenic factors or signaling pathways such as PTEN, CDK, caspase, E-cadherin, Akt, and P53. Greater recognition of the roles of miRNAs and lncRNAs in gastric carcinogenesis can provide new insight into the mechanisms of tumor development and identify targets for anticancer drug development.

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