Efficient synthesis of chiral 尾-and 纬-N-tosylaminoalcohols from 1-aryl-2-aminopropane-1,3-diols

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• 作者：Xichun Feng (1)
  Guofu Qiu (1)
  Shucai Liang (1)
  Jiangtao Su (1)
  Hanbing Teng (1)
  Lamei Wu (1)
  Xianming Hu (1)
  
• 刊名：Russian Journal of Organic Chemistry
• 出版年：2006
• 出版时间：April 2006
• 年：2006
• 卷：42
• 期：4
• 页码：496-500
• 全文大小：153KB
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• 作者单位：Xichun Feng (1)
  Guofu Qiu (1)
  Shucai Liang (1)
  Jiangtao Su (1)
  Hanbing Teng (1)
  Lamei Wu (1)
  Xianming Hu (1)
  
  1. College of Pharmacy, Wuhan University, Wuhan, 430072, China
  
• ISSN：1608-3393

文摘

(1S,2S)-1-Aryl-2-tozylaminopropan-1-ols were synthesized by cyclization of 1-aryl-2-aminopropane-1,3-diol to aryl(1-tosylaziridin-2-yl)methanols, followed by hydride reduction of the latter. Reduction of the aza-Payne rearrangement products of intermediate aryl(1-tosylaziridin-2-yl)methanols gave (1S)-1-aryl-3-tosylaminopropan-1-ols.