Banhabaekchulchunma-tang, a traditional herbal formula attenuates absolute ethanol-induced gastric injury by enhancing the antioxidant status
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- 作者：In-Sik Shin (6)
Woo-Young Jeon (6)
Hyeun-Kyoo Shin (6)
Sin-Woo Cha (7)
Mee-Young Lee (6) - 关键词：Banhabaekchulchunma ; tang ; Herbal formula ; Ethanol ; Gastric injury ; Antioxidant
- 刊名：BMC Complementary and Alternative Medicine
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：13
- 期：1
- 全文大小：1244KB
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33. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6882/13/170/prepub - 作者单位：In-Sik Shin (6)
Woo-Young Jeon (6)
Hyeun-Kyoo Shin (6)
Sin-Woo Cha (7)
Mee-Young Lee (6)
6. Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, 483 Expo-ro, Yusung-gu, Daejeon, 305-811, Republic of Korea
7. Department of Nonclinical Studies, Korea Institute of Toxicology, 141 Gajeong-ro, Yusung-gu, Daejeon, 305-343, Republic of Korea
文摘
Background Banhabaekchulchunma-tang (hange-byakujutsu-tenma-to in Japanese and banxia-baizhu-tianma-tang in Chinese) is a mixture of fourteen herbs. It is used traditionally for the treatment of anemia, anorexia, general weakness, and female infertility in China, Japan, and Korea. In this study, we investigated the protective effects of a Banhabaekchulchunma-tang water extract (BCT) against ethanol-induced acute gastric injury in rats. Methods Gastric injury was induced by intragastric administration of 5?mL/kg body weight of absolute ethanol to each rat. The positive control group and the BCT group were given oral doses of omeprazole (50?mg/kg) or BCT (400?mg/kg), respectively, 2?h prior to the administration of absolute ethanol. The stomach of each animal was excised and examined for gastric mucosal lesions. To confirm the protective effects of BCT, we evaluated the degree of lipid peroxidation, the level of reduced glutathione (GSH), and the activities of the antioxidant enzymes catalase, glutathione-S-transferase, glutathione peroxidase, and glutathione reductase in the stomach. In addition, we conducted an acute toxicity study to evaluate the safety of BCT according to OECD guideline. Results BCT reduced ethanol-induced hemorrhage, hyperemia, and loss of epithelial cell in the gastric mucosa. BCT reduced the increased lipid peroxidation associated with ethanol-induced acute gastric lesions, and increased the mucosal GSH content and the activities of antioxidant enzymes. In addition, BCT did not cause any adverse effects at up to 5000?mg/kg. Conclusions These results indicate that BCT protects the gastric mucosa against ethanol-induced gastric injury by increasing the antioxidant status. We suggest that BCT could be developed as an effective drug for the treatment of gastric injury caused by alcohol intake.