Clinical and microbiological characteristics of Klebsiella pneumoniae liver abscess in East China

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• 作者：Ting-ting Qu (1) (4)
  Jian-cang Zhou (2)
  Yan Jiang (2)
  Ke-ren Shi (2)
  Bin Li (3)
  Ping Shen (1)
  Ze-qing Wei (1)
  Yun-song Yu (1) (2)
  
  1. State Key Laboratory for Diagnosis and treatment of Infectious Disease ; First Affiliated Hospital ; College of Medicine ; Zhejiang University ; 3# Qingchun East Road ; Hangzhou ; 310016 ; China
  4. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases ; Hangzhou ; Zhejiang ; China
  2. Department of Infectious Diseases ; Sir Run Run Shaw Hospital ; College of Medicine ; Zhejiang University ; Hangzhou ; Zhejiang ; China
  3. Department of Infectious Diseases ; Forth Affiliated Hospital ; College of Medicine ; Zhejiang University ; Yiwu ; Zhejiang ; China
  
• 关键词：Klebsiella pneumoniae ; K. pneumoniae liver abscess (KLA) ; Hypermucoviscous ; magA ; Multilocus sequence typing (MLST)
• 刊名：BMC Infectious Diseases
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：15
• 期：1
• 全文大小：577 KB
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• 刊物主题：Infectious Diseases; Parasitology; Medical Microbiology; Tropical Medicine; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2334

文摘

Background Klebsiella pneumoniae has been the dominant pathogen for liver abscesses in several Asian countries. Although the prevalence of K. pneumoniae liver abscess (KLA) in mainland China is increasing recently, the clinical and microbiological characteristics of KLA in China have not been elucidated. Methods Clinical and microbiology characteristics of 45 consecutive patients with KLA from a tertiary teaching hospital in China between June 2008 and June 2012 were retrospectively evaluated. Results Vast majority of the strains were susceptible to main antimicrobial agents. Most of K. pneumoniae strains from pyogenic liver abscess patients belonged to K1/K2 serotype (68.9% for K1 serotype and 20% for K2 serotype). All K. pneumoniae strains were rmpA positive, and 68.9% of these strains were magA positive. Overall, 57.8% (26/45) of K. pneumoniae strains belonged to ST23. Twenty-five of 26 ST23 K. pneumoniae isolates (96.2%) from KLA patients were magA-positive and K1 serotype. Only 28.9% (13/45) of KLA isolates exhibited hypermucoviscous phenotype, which is clinically used as the characteristic of hypervirulent K. pneumoniae (hvKP). Liver abscess sizes in patients infected with hvKP were tend to be larger than those in patients infected with cKP. There was no significant association between the microbiological and clinical characteristics including serotypes, magA and rmpA genotypes, and STs with the metastatic infection and prognosis of KLA. Conclusions Neither the serotypes, magA and rmpA genotypes, nor the STs of K. pneumoniae were associated with the metastatic infection and prognosis of KLA. However, further studies with larger sample are needed in the future.