A modified St?ber process for the production of mesoporous Sub 2 micron silica microspheres; applications in HPLC

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• 作者：D. A. Keane ; J. P. Hanrahan ; M. P. Copley ; J. D. Holmes and M. A. Morris
• 关键词：Monodisperse ; Mesoporous silica ; Spheres ; Pore expansion ; HPLC
• 刊名：Journal of Porous Materials
• 出版年：2010
• 出版时间：April, 2010
• 年：2010
• 卷：17
• 期：2
• 页码：145-152
• 全文大小：511.9 KB

文摘

Mesoporous silica microspheres in the 1–2 μm range with good size monodispersivity were synthesized by ammonia catalysed hydrolysis and condensation of tetraethylorthosilicate using methanol as solvent and cetyltrimethylammonium bromide as surfactant porogen. The mesopore diameter was subsequently expanded from <20 ? to ~200 ? by a postsynthesis hydrothermal treatment in a water–amine emulsion system followed by controlled dissolution in aqueous alkali. XRD, TEM, and N₂ sorption measurements were used to characterize pore properties. Particle size measurements in conjunction with SEM were used to establish morphology and size distribution. Preliminary chromatographic results are presented which demonstrate the applicability of these particles in High Performance Liquid Chromatography (HPLC). The particle size, porosity and chromatographic performance of the particles are compared to commercial HPLC silicas.