Development and Validation of an HPLC Method for Determination of Amikacin in Water Samples by Solid Phase Extraction and Pre-column Derivatization

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• 作者：Deguang Li (1) (2)
  Shun He (1)
  Yufang Deng (1)
  Guanglong Ding (1)
  Hanwen Ni (1)
  Yongsong Cao (1)
  
• 关键词：Amikacin ; Residue determination ; Solid phase extraction ; Pre ; column derivatization ; High performance liquid chromatography
• 刊名：Bulletin of Environmental Contamination and Toxicology
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：93
• 期：1
• 页码：47-52
• 全文大小：
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• 作者单位：Deguang Li (1) (2)
  Shun He (1)
  Yufang Deng (1)
  Guanglong Ding (1)
  Hanwen Ni (1)
  Yongsong Cao (1)
  
  1. College of Agriculture and Biotechnology, China Agricultural University, Beijing, China
  2. Beijing Industrial Technology Research Institute, Beijing, China
  
• ISSN：1432-0800

文摘

This work presents a rapid and sensitive high performance liquid chromatography method for the determination of amikacin in water samples with solid phase extraction and pre-column derivatization. Amikacin residue was extracted from water samples with solid phase extraction cartridge. Then the extraction solution was derivatized with 4-chloro-3,5-dinitrobenzotrifluoride in the presence of triethylamine at 70°C in 20?min. The amikacin derivative was separated on a C18 column and detected by application of UV detection at 238?nm. The limit of detection is 0.2?μg/L with a signal-to-noise ratio of 3 and linearity is established over the concentration range from 0 to 500.0?μg/L. Recoveries of the amikacin in three types of water samples are from 87.5?% to 99.6?% and RSDs are 2.1?%-.5?%. This method can be used for the quantification of amikacin residues in water samples.