IGF1 3′UTR functions as a ceRNA in promoting angiogenesis by sponging miR-29 family in osteosarcoma
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- 作者：Shuming Gao ; Cai Cheng ; Hanwen Chen ; Min Li ; Kehun Liu…
- 关键词：Osteosarcoma ; IGF1 ; ceRNA ; VEGF ; miR ; 29a ; miR ; 29b ; miR ; 29c ; Angiogenesis
- 刊名：Journal of Molecular Histology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：47
- 期：2
- 页码：135-143
- 全文大小：1,635 KB
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Cai Cheng (1)
Hanwen Chen (1)
Min Li (1)
Kehun Liu (1)
Guangya Wang (1)
1. Department of orthopaedics, Cangzhou Central Hospital, Xinhua Road, Cangzhou, Hebei Province, China - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Cell Biology
Biomedicine
Developmental Biology - 出版者：Springer Netherlands
- ISSN：1567-2387
文摘
Osteosarcoma is one of the most common malignant bone tumors in human worldwide. Angiogenesis is a pivotal process during osteosarcoma development. Insulin-like growth factor 1 (IGF1) has been reported to promote angiogenesis. However, the role of 3′ untranslational region (3′UTR) of IGF1 mRNA in angiogenic activity in osteosarcomas is still unknown. In the present study, we performed gain-of-function assays to investigate the role of IGF1-3′UTR in angiogenesis. For the first time, we demonstrated that IGF1 3′UTR increased VEGF expression and promotes angiogenesis in osteosarcoma cells. In addition, RNA-immunoprecipitation and luciferase reporter assays showed that IGF1 3′UTR was a direct target of miR-29s. Our data also demonstrated that there existed a competition of miR-29s between IGF1-3′UTR and VEGF mRNA, and IGF1-3′UTR promoted angiogenesis at least in part via sponging miR-29s. Taken together, our study suggests that IGF1-3′UTR functions as a ceRNA in promoting angiogenesis by sponging miR-29s in osteosarcoma.