Dual-stimuli responsive polymeric micelles: preparation, characterization, and controlled drug release

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• 作者：Wen-Chung Wu ; Yu-Sheng Kuo ; Chung-Hao Cheng
• 关键词：Amphiphilic block copolymer ; Micelle ; Stimuli ; responsive ; LCST ; Controlled drug release
• 刊名：Journal of Polymer Research
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：22
• 期：5
• 全文大小：2,033 KB
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• 作者单位：Wen-Chung Wu (1)
  Yu-Sheng Kuo (1)
  Chung-Hao Cheng (1)
  
  1. Department of Chemical Engineering, National Cheng Kung University, 1 University Road, Tainan, 70101, Taiwan
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Polymer Sciences
  Industrial Chemistry and Chemical Engineering
  Characterization and Evaluation Materials
  
• 出版者：Springer Netherlands
• ISSN：1572-8935

文摘

The preparation of stimuli-responsive polymeric micelles sensitive to both temperature and UV irradiation is achieved through the self-assembly from a series of amphiphilic block copolymers, poly(triethylene glycol methacrylate)-b-poly(2-nitrobenzyl methacrylate) (PTEGMA-b-PNBMA). The block ratios of the hydrophilic and thermo-responsive PTEGMA block to the hydrophobic and photoclevable PNBMA block are manipulated in the range of 4:1 to 1:1. The nanostructure and stimuli-responsive properties of the micelles are well-correlated with the chemical structures of the copolymers. The thermal transition temperature of micelles is reduced to 38–41 °C and close to body temperature as compared to that of PTEGMA homopolymer around 52 °C. After UV irradiation, the enhanced hydrophilicity of micelle core causes swelling and increased size of micelles. The capabilities of these micelles for drug encapsulation are demonstrated by using doxorubicin as the model drug and the subsequent drug release could be triggered by elevated temperature and/or UV irradiation. Furthermore, the potential application of these micelles in controlled drug release is explored by studying the in vitro cytotoxicity of drug-loaded micelles as triggered by external stimuli.