CD28/CTLA-4/ICOS haplotypes confers susceptibility to Graves’ disease and modulates clinical phenotype of disease

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• 作者：Edyta Pawlak-Adamska ; Irena Frydecka ; Marek Bolanowski ; Anna Tomkiewicz…
• 关键词：CD28/CTLA ; 4/ICOS ; Graves’ disease ; Graves’ orbitopathy ; Gene polymorphism ; Haplotype
• 刊名：Endocrine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：55
• 期：1
• 页码：186-199
• 全文大小：399KB
• 刊物主题：Endocrinology; Diabetes; Internal Medicine; Science, Humanities and Social Sciences, multidisciplinary;
• 出版者：Springer US
• ISSN：1559-0100
• 卷排序：55

文摘

Graves’ disease, an autoimmune disease with heterogeneous symptoms including Graves’ orbitopathy, has a combined genetic/environmental background, where variations within CD28/CTLA-4/ICOS genes are considered as disease markers.