Increased Radiosensitivity as an Indicator of Genes Conferring Breast Cancer Susceptibility
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- 作者：Dominic Varga* ; Walther Vogel* ; Ariane Bender ; Harald Surowy ; Christiane Maier ; Rolf Kreienberg ; Helmut Deissler and Georg Sauer
- 关键词：Key Words ; BRCA ; Breast cancer ; Micronucleus test ; Radiosensitivity
- 刊名：Strahlentherapie und Onkologie
- 出版年：2007
- 出版时间：December, 2007
- 年：2007
- 卷：183
- 期：12
- 页码：655-660
- 全文大小：274.8 KB
- 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Radiotherapy
Oncology - 出版者：Urban & Vogel
- ISSN：1439-099X
文摘
Purpose: This paper briefly summarizes the research on increased radiosensitivity in breast cancer patients measured by the micronucleus test (MNT) and its association to genetic variants in DNA repair genes. More preliminary data are presented on the distribution of chromosomes and chromosome fragments in micronuclei (MN) in order to gain more information on clastogenic and aneugenic effects and better understand the phenotype of increased radiosensitivity.