Mitochondriale Transhydrogenase: Yin und Yang der antioxidativen Kapazität

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• 作者：Albrecht Von Hardenberg ; Alexander Nickel ; Christoph Maack
• 刊名：BIOspektrum
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：23
• 期：1
• 页码：22-24
• 全文大小：
• 刊物主题：Life Sciences, general; Biochemistry, general; Human Genetics; Microbiology; Developmental Biology; Pharmacology/Toxicology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1868-6249
• 卷排序：23

文摘

Mitochondria are the main source for ATP, but also reactive oxygen species (ROS). While NADH is required for ATP production, NADPH regenerates anti-oxidative capacity to prevent excessive ROS emission. The mitochondrial transhydrogenase links NADH with NADPH pools and is mutated in C57BL/6 mice from Jackson Laboratories. While in most scenarios, the transhydrogenase regenerates NADPH in the forward mode, it can reverse under pathological conditions and cause oxidative stress and heart failure.