Human herpesvirus 6 infection impairs Toll-like receptor signaling
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- 作者：Yuichi Murakami (1)
Kazushi Tanimoto (1)
Hiroshi Fujiwara (1) (2)
Jun An (1)
Koichiro Suemori (1)
Toshiki Ochi (1)
Hitoshi Hasegawa (1) (2)
Masaki Yasukawa (1) (2) - 刊名：Virology Journal
- 出版年：2010
- 出版时间：December 2010
- 年：2010
- 卷：7
- 期：1
- 全文大小：1022KB
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Kazushi Tanimoto (1)
Hiroshi Fujiwara (1) (2)
Jun An (1)
Koichiro Suemori (1)
Toshiki Ochi (1)
Hitoshi Hasegawa (1) (2)
Masaki Yasukawa (1) (2)
1. Departmemt of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, 791-0295, Japan
2. Proteo-Medicine Research Center, Ehime University, Toon, Ehime, 791-0295, Japan - ISSN：1743-422X
文摘
Human herpesvirus 6 (HHV-6) has a tropism for immunocompetent cells, including T lymphocytes, monocytes/macrophages, and dendritic cells (DCs) suggesting that HHV-6 infection affects the immunosurveillance system. Toll-like receptor (TLR) system plays an important role in innate immunity against various pathogens. In the present study, we investigated the effect of HHV-6 infection on the expression and intracellular signaling of TLRs in DCs. Although expression levels of TLRs were not decreased or slightly elevated following HHV-6 infection, the amounts of cytokines produced following stimulation with ligands for TLRs appeared to be dramatically decreased in HHV-6-infected DCs as compared to mock-infected DCs. Similarly, phosphorylation levels of TAK-1, IκB kinase, and IκB-α following stimulation of HHV-6-infected DCs with lipopolysaccharide, which is the ligand for TLR4, appeared to be decreased. These data show that HHV-6 impairs intracellular signaling through TLRs indicating the novel mechanism of HHV-6-mediated immunomodulation.