Host specificity and in vivo infectivities of the mouse coccidian parasites Eimeria krijgsmanni

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• 作者：Kazuki Hashimoto (1)
  Tetsuya Tanaka (2)
  Makoto Matsubayashi (3)
  Kyoko Endo (4)
  Rika Umemiya-Shirafuji (5)
  Toshihiro Matsui (6)
  Tomohide Matsuo (1)
  
• 关键词：Eimeria ; mouse ; macrophage ; NK cell
• 刊名：Acta Parasitologica
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：59
• 期：2
• 页码：337-342
• 全文大小：
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• 作者单位：Kazuki Hashimoto (1)
  Tetsuya Tanaka (2)
  Makoto Matsubayashi (3)
  Kyoko Endo (4)
  Rika Umemiya-Shirafuji (5)
  Toshihiro Matsui (6)
  Tomohide Matsuo (1)
  
  1. Laboratory of Parasitology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, 890-0065, Japan
  2. Laboratory of Emerging Infectious Diseases, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, 890-0065, Japan
  3. Laboratory of Protozoan Diseases, National Institute of Animal Health, Tsukuba, 305-0856, Japan
  4. Kyorin University School of Health Science, Tokyo, 192-8508, Japan
  5. National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, 080-8555, Japan
  6. Division of Tropical Diseases and Parasitology, Kyorin University School of Medicine, Tokyo, 181-8611, Japan
  
• ISSN：1896-1851

文摘

In the present study, infection experiments of E. krijgsmanni using various hosts were conducted to elucidate the host specificity among some animals and the infectivity to mouse strains. According to the results, the infection was not found in most animals, except for rats, in which some oocyst shedding was detected, and there was no significant difference in infectivity among mouse strains. Additionally, oocyst shedding was hardly detectable in a secondary infection to immunocompetent mice, although it was found in immunodeficient mice. These results indicated that only immunocompetent mice could develop adaptive immunity against reinfection by stimuli of the primary infection. Furthermore, the infection experiments were performed with splenic macrophage (Mφ)-depleted mice with a reagent and Beige (Bg) mice known to be a strain of mice with low NK cell activity. No significant effect was found in primary or secondary infections in the Mφ-depleted mice, whereas the mortality rate was clearly increased in Bg mice inoculated with a large number of oocysts. Their oocyst shedding was similar to that of immunocompetent hosts. Taken together, these results suggested that Mφ has only a minor role in the immune response, but the NK cell has an important function in resistance to primary infection of E. krijgsmanni.