Water-pipe smoking effects on pulmonary permeability using technetium-99m DTPA inhalation scintigraphy

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• 作者：Aysel Aydin (1)
  Goksel Kiter (2)
  Hatice Durak (1)
  Eyup Sabri Ucan (3)
  Gamze Capa Kaya (1)
  Emel Ceylan (3)
  
• 关键词：water ; pipe smoking ; pulmonary function ; technetium ; 99m diethylenetriamine ; pentaacetic acid ; inhalation scintigraphy
• 刊名：Annals of Nuclear Medicine
• 出版年：2004
• 出版时间：June 2004
• 年：2004
• 卷：18
• 期：4
• 页码：285-289
• 全文大小：653KB
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• 作者单位：Aysel Aydin (1)
  Goksel Kiter (2)
  Hatice Durak (1)
  Eyup Sabri Ucan (3)
  Gamze Capa Kaya (1)
  Emel Ceylan (3)
  
  1. Department of Nuclear Medicine, Dokuz Eylul University School of Medicine, 35340, Izmir, Turkey
  2. Department of Chest Diseases, Pamukkale University, Medical Faculty, Denizli, Turkey
  3. Department of Chest Diseases, Dokuz Eylul University School of Medicine, Izmir, Turkey
  

文摘

Objective Although extensive work has been done on cigarette smoking and its effects on pulmonary function, there are limited number of studies on water-pipe smoking. The effects of water-pipe smoking on health are not widely investigated. The aim of this study was to determine the effects of water-pipe smoking on pulmonary permeability. Methods Technetium-99m DTPA inhalation scintigraphy was performed on 14 water-pipe smoker volunteers (all men, mean age 53.7 ± 9.8) and 11 passive smoker volunteers (1 woman, 10 men, mean age 43.8 ± 12). Clearance half-time (T 1/2) was calculated by placing a monoexponential fit on the time activity curves. Penetration index (PI) of the radioaerosol was also calculated. Results PI was 0.58 ±0.14 and 0.50 ± 0.12 for water-pipe smokers (WPS) and passive smokers (PS) respectively. T1/2 of peripheral lung was 57.3 ± 12.7 and 64.6 ± 13.2 min, central airways was 55.8 ± 23.5 and 80.1 ± 35.2 min for WPS and PS, respectively (p ?0.05). FEV1/FVC% was 82.1 ± 8.5 (%) and 87.7 ± 6.5 (%) for WPS and PS, respectively (0.025 < p ?0.05). Conclusions We suggest that water-pipe smoking effects pulmonary epithelial permeability more than passive smoking. Increased central mucociliary clearance in water-pipe smoking may be due to preserved humidity of the airway tracts.