The use of microRNA by human viruses: lessons from NK cells and HCMV infection
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- 作者：Tal Goldberger (1)
Ofer Mandelboim (1) - 关键词：HCMV ; NK cells ; MicroRNA ; Cytomegalovirus ; Immune modulation ; Immune evasion
- 刊名：Seminars in Immunopathology
- 出版年：2014
- 出版时间：November 2014
- 年：2014
- 卷：36
- 期：6
- 页码：659-674
- 全文大小：1,022 KB
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Ofer Mandelboim (1)
1. The Lautenberg Center of General and Tumor Immunology, The Hebrew University Hadassah Medical School, IMRIC, Jerusalem, 91120, Israel - ISSN：1863-2300
文摘
Depending on ethnicity and on social conditions, between 40 and 90?% of the population is infected with human cytomegalovirus (HCMV). In immunocompetent patients, the virus may cause an acute disease and then revert to a state of latency, which enables its coexistence with the human host. However, in cases of immunosuppression or in neonatal infections, HCMV can cause serious long-lasting illnesses. HCMV has developed multiple mechanisms in order to escape its elimination by the immune system, specifically by two killer cell types of the adaptive and the innate immune systems; cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, respectively. Another fascinating aspect of HCMV is that like other highly developed herpesviruses, it expresses its own unique set of microRNAs. Here, we initially describe how the activity of NK cells is regulated under normal conditions and during infection. Then, we discuss what is currently known about HCMV microRNA-mediated interactions, with special emphasis on immune modulation and NK cell evasion. We further illustrate the significant modulation of cellular microRNAs during HCMV infection. Although, the full target spectrum of HCMV microRNAs is far from being completely elucidated, it can already be concluded that HCMV uses its “multitasking-microRNAs to globally affect its own life cycle, as well as important cellular and immune-related pathways.