Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth

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• 作者：Lunshan Xu (2)
  Xiangwei Wang (1)
  Jianhua Wan (3)
  Tai Li (3)
  Xueyang Gong (3)
  Kui Zhang (3)
  Liang Yi (2)
  Zhonghuai Xiang (3)
  Minhui Xu (2) minhuixu66@yahoo.com.cn
  Hongjuan Cui (3) hcui@swu.edu.cn
• 关键词：Cyclopamine – ; Sonic Hedgehog – ; Neuroblastoma – ; Proliferation – ; Tumor growth
• 刊名：Molecular and Cellular Biochemistry
• 出版年：2012
• 出版时间：May 2012
• 年：2012
• 卷：364
• 期：1-2
• 页码：235-241
• 全文大小：586.4 KB
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• 作者单位：1. Department of Urology, Center of Nephropathy, Second Affiliated Hospital, Third Military Medical University, Chongqing, China2. Department of Neurosurgery, Daping Hospital, Third Military Medical University, No.10, Changjiang Zhilu, Daping, Yuzhong District, Chongqing, 400042 China3. State Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, 216 Tiansheng Road, Beibei District, Chongqing, 400716 China
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Medical Biochemistry
  Oncology
  Cardiology
  
• 出版者：Springer Netherlands
• ISSN：1573-4919

文摘

Accumulated evidence suggests a major role for the activation of the Sonic Hedgehog (SHH) signaling pathway in the development of neural crest stem cells that give rise to the sympathetic nervous system. We therefore investigated the involvement of SHH signaling in the pathogenesis of neuroblastoma (NB), a common childhood malignant tumor of the sympathetic nervous system. Inhibition of SHH signaling by cyclopamine induced apoptosis and blocked proliferation in all major types of NB cells, and abrogated the tumorigenicity of NB cells. Our study has revealed a molecular mechanism for the persistent activation of the SHH pathway which promotes the development of NB, and suggests a new approach for the treatment of this childhood malignant tumor.