Role of Sonic Hedgehog (Shh) Signaling in Bladder Cancer Stemness and Tumorigenesis
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  • 作者：Islam S. Syed ; Akbari Pedram ; Walid A. Farhat
  • 关键词：Sonic hedgehog signaling ; Regenerative medicine ; Bladder cancer
  • 刊名：Current Urology Reports
  • 出版年：2016
  • 出版时间：February 2016
  • 年：2016
  • 卷：17
  • 期：2
  • 全文大小：491 KB
  • 参考文献：1.American Cancer Society; 2015.
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  • 作者单位：Islam S. Syed (1) (2)
    Akbari Pedram (1)
    Walid A. Farhat (1)

    1. Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada
    2. Cancer Biology and Experimental Therapeutic Section, Division of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia
  • 刊物主题：Urology/Andrology; Nephrology;
  • 出版者：Springer US
  • ISSN：1534-6285
    • 文摘
    Sonic hedgehog (Shh) signaling pathway has emerged as a critical component of bladder development, cancer initiation, and progression. While the role of Shh signaling in bladder development is well documented, its role in bladder cancer progression is uncertain. Additionally, epithelial-to-mesenchymal transition (EMT) has been identified to promote bladder cancer progression in the initial stages and also contribute to drug resistance in the later stage and ultimately metastasis. We speculate that epithelial-to-mesenchymal transitions (EMT) and Shh fuel the carcinogenesis process. This review presents the most recent studies focusing on the role of Shh signaling in bladder cancer progression

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