Monosomal karyotype in acute myeloid leukemia and the role of allogeneic hematopoietic cell transplantation

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• 作者：Yunsuk Choi ; Je-Hwan Lee ; Eul-Ju Seo ; Jung-Hee Lee ; Dae-Young Kim…
• 关键词：Acute myeloid leukemia ; Monosomal karyotype ; Complex karyotype ; Prognostic factor ; Allogenetic hematopoietic stem cell transplantation
• 刊名：Annals of Hematology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：94
• 期：5
• 页码：795-801
• 全文大小：219 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Hematology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0584

文摘

Monosomal karyotype (MK) in acute myeloid leukemia (AML) is associated with an extremely poor outcome. The clinical significance of MK and the role of allogeneic hematopoietic cell transplantation (HCT) were evaluated in 749 Korean patients with newly diagnosed AML. MK was found in 9.3?% of patients and was more frequent in patients with advanced age or secondary AML. Patients with MK had significantly lower blood leukocyte counts and bone marrow blast percentages, and they had lower complete remission (CR) rate (43?%) and shorter median overall survival (OS) (6.5?months) and relapse-free survival (RFS) (10.0?months) than any other prognostic group. MK+ patients who received allogeneic HCT at the first CR had higher OS [hazard ratio (HR) 0.344, P--.018], RFS (HR 0.257, P--.006), and lower relapse probability (HR 0.264, P--.008) than those not receiving. This study’s results confirmed poor outcomes for AML patients with MK and suggest that allogeneic HCT at the first CR may improve outcome.