Interdisziplinäre Therapie des Rektumkarzinoms

详细信息    查看全文

• 作者：C. Rimkus ; H. Seidl ; W. Heiland ; PD Dr. F. G. Bader
• 关键词：Staging ; Prognose ; Multimodale Behandlung ; Bestrahlung ; Radiochemotherapie ; Staging ; Prognosis ; Multimodal treatment ; Radiation ; Radiochemotherapy
• 刊名：Der Gastroenterologe
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：11
• 期：1
• 页码：55-69
• 全文大小：850 KB
• 参考文献：1.Stelzner F (2006) Zellvermehrungsselbstkontrolle der polypösen Adenome und Karzinogenese in der Kolorektalregion. Chirurg 11:1048–1055CrossRef
  2.Stelzner F, Friedrichs N, von Mallek (2009) Hüllfaszien, Homingareal und Lymphgefäße sind krebsarretierend. Chirurg 80(3):216–222CrossRef
  3.Levy M, Visokai V, Lipska L et al (2008) Tumor markers in staging and prognosis of colorectal carcinoma. Neoplasma 55(2):138–142PubMed
  4.Bipat S, Glas A, Slors F et al (2004) Rectal cancer: local staging and assessment of lymph node involvement with Endoluminal US, CT, and MR imaging – a meta-analysis. Radiology 232(3):773–783CrossRef PubMed
  5.MERCURY Study Group (2006) Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study. BMJ 333(7572):779PubMedCentral CrossRef
  6.Nagategaal JD, Quirke P (2008) What is the role for the circumferential margin in the modern treatment of rectal cancer? J Clin Oncol 26:303–312CrossRef
  7.Smith NJ, Barbachano Y, Norman AR et al (2008) Prognostic significance of magnetic resonance imaging-detected extramural vascular invasion in rectal cancer. Br J Surg 95:229–236CrossRef PubMed
  8.Rödel C, Liersch T, Becker H et al (2012) Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial. Lancet 13(7):679–687CrossRef PubMed
  9.Rödel C, Martus P, Papadoupolos T et al (2005) Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol 23(34):8688–8696CrossRef PubMed
  10.Heo SH, Kim JW, Shin S et al (2014) Multimodal imaging evaluation in staging of rectal cancer. World J Gastroenterol 20(15):4244–4255PubMedCentral CrossRef PubMed
  11.Guillem JG, Díaz-González J, Minsky BD et al (2008) cT3N0 rectal cancer: potential Overtreatment with preoperative Chemoradiotherapy is warranted. JCO 26(3):368–373CrossRef
  12.Bosset JF, Collette L, Calais G et al (2006) Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 355(11):1114–1123CrossRef PubMed
  13.Kauer WK, Prantl L, Dittler HJ et al (2004) The value of endosonographic rectal carcinoma staging in routine diagnostics: a 10-year analysis. Surg Endosc 18(7):1075–1078CrossRef PubMed
  14.Folkesson J, Birgisson H, Pahlman L et al (2005) Swedish rectal cancer trial: long lasting benefits from radiotherapy on survival and local recurrence rate. J Clin Oncol 23(24):5644–5650CrossRef PubMed
  15.Swedish Rectal Cancer Trial (1997) Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med 336:980–987CrossRef
  16.Pettersson D, Cedermark B, Holm T et al (2010) Interim analysis of the Stockholm III trial of preoperative radiotherapy regimens for rectal cancer. Br J Surg 97(4):580–587CrossRef PubMed
  17.Pettersson D, Holm T, Iversen H et al (2012) Preoperative short-course radiotherapy with delayed surgery in primary rectal cancer. Br J Surg 99(4):577–583CrossRef PubMed
  18.Peeters KC, Marijnen CA, Nagtegaal ID et al (2007) The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg 246(5):693–701CrossRef PubMed
  19.Van Gijn W, Marijnen CA, Nagtegaal ID et al (2011) Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial. Lancet Oncol 12(6):575–582CrossRef PubMed
  20.Sebag-Montefiore D, Stephens RJ, Steele R et al (2009) Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet 373(9666):811–820PubMedCentral CrossRef PubMed
  21.Gerard JP, Conroy T, Bonnetain F et al (2006) Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3–T4 rectal cancers: results of FFCD 9203. J Clin Oncol 24(28):4620–4625CrossRef PubMed
  22.Sauer R, Becker H, Hohenberger W et al (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351(17):1731–1740CrossRef PubMed
  23.Roh MS, Colangelo LH, O’Connell MJ et al (2009) Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03. J Clin Oncol 27(31):5124–5130PubMedCentral CrossRef PubMed
  24.Hofheinz RD, Wenz F, Post S et al (2012) Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial. Lancet Oncol 13(6):579–588CrossRef PubMed
  25.Aschele C, Cionini L, Lonardi S et al (2011) Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial. J Clin Oncol 29(20):2773–2780CrossRef PubMed
  26.Pettersson D, Glimelius B, Iversen H et al (2013) Impaired postoperative leucocyte counts after preoperative radiotherapy for rectal cancer in the Stockholm III Trial. Br J Surg 100(7):969–975CrossRef PubMed
  27.Veenhof AA, Bloemena E, Engel AF et al (2009) The relationship of histological tumor regression grade (TRG) and two different time intervals to surgery following radiation therapy for locally advanced rectal cancer. Int J Colorectal Dis 24(9):1091–1096CrossRef PubMed
  28.Cummings BJ, Rider WD, Harwood AR (1983) Radical external beam radiation therapy for adenocarcinoma of the rectum. Dis Colon Rectum 26:30–36CrossRef PubMed
  29.Graf W, Dahlberg M, Mazloum-Osman M et al (1997) Short-term preoperative radiotherapy results in down staging of rectal cancer: a study of 1316 patients. Radiother Oncol 43:133–137CrossRef PubMed
  30.Sloothaak DA, Geijsen DE, van Leersum NJ et al (2013) Optimal time interval between neoadjuvant chemoradiotherapy and surgery for rectal cancer. Br J Surg 100:933–939CrossRef PubMed
  31.Petrelli F, Sgroi G, Sarti E et al (2013) Increasing the interval between neoadjuvant chemoradiotherapy and surgery in rectal cancer: A meta-analysis of published studies. Ann Surg
  32.Bengt G (2014) Optimal time intervals between pre-operative radiotherapy or chemoradiotherapy and surgery in rectal cancer? Front Oncol 4:50
  33.Stein DE, Mahmoud NN, Anne PR et al (2003) Longer time interval between completion of neoadjuvant chemoradiation and surgical resection does not improve downstaging of rectal carcinoma. Dis Colon Rectum 46(4):448–453CrossRef PubMed
  34.Lim SB, Choi HS, Jeong SY et al (2008) Optimal surgery time after preoperative chemoradiotherapy for locally advanced rectal cancers. Ann Surg 248(2):243–251CrossRef PubMed
  35.Francois Y, Nemoz CJ, Baulieux J et al (1999) Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: the Lyon R90-01 randomized trial. J Clin Oncol 17(8):2396–2402PubMed
  36.Garcia-Aguilar J, Hernandez de Anda E, Sirivongs P et al (2003) A pathologic complete response to preoperative chemoradiation is associated with lower local recurrence and improved survival in rectal cancer patients treated by mesorectal excision. Dis Colon Rectum 46(3):298–304CrossRef PubMed
  37.Vecchio FM, Valentini V, Minsky BD et al (2005) The relationship of pathologic tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer. Int J Radiat Oncol Biol Phys 62(3):752–760CrossRef PubMed
  38.Maas M, Nelemans PJ, Valentini V et al (2010) Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data. Lancet Oncol 11(9):835–844CrossRef PubMed
  39.Hartley A, Giridharan S, Gray L et al (2002) Retrospective study of acute toxicity following short-course preoperative radiotherapy. Br J Surg 89(7):889–895CrossRef PubMed
  40.Fokstuen T, Holm T, Glimelius B (2009) Postoperative morbidity and mortality in relation to leukocyte counts and time to surgery after short-course preoperative radiotherapy for rectal cancer. Radiother Oncol 93(2):293–297CrossRef PubMed
  41.Jakobsen A, Ploen J, Vuong T et al (2012) Dose-effect relationship in chemoradiotherapy for locally advanced rectal cancer: a randomized trial comparing two radiation doses. Int J Radiat Oncol Biol Phys 84(4):949–954CrossRef PubMed
  42.Ueno H, Mochizuki H, Hashiguchi Y et al (2004) Risk factors for an adverse outcome in early invasive colorectal carcinoma. Gastroenterology 127(2):385–394CrossRef PubMed
  43.Participants in the Paris Workshop (2003) The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon. Gastrointest Endosc 58(6 Suppl):3–43
  44.Nascimbeni R, Burgart LJ, Nivatvongs S et al (2002) Risk of lymph node metastasis in T1 carcinoma of the colon and rectum. Dis Colon Rectum 45(2):200–206CrossRef PubMed
  45.Carrara A, Mangiola D, Pertile R et al (2012) Analysis of Risk Factors for Lymph Nodal Involvement in Early Stages of Rectal Cancer: When Can Local Excision Be Considered an Appropriate Treatment? Systematic Review and Meta-Analysis of the Literature. Int J Surg Oncol 2012:Article ID 438450 doi:10.1155/2012/438450
  46.Tanaka S, Kashida H, Saito Y et al (2015) JGES guidelines for colorectal endoscopic submucosal dissection/endoscopic mucosal resection. Dig Endosc 27(4):417–434CrossRef PubMed
  47.Fazio VW, Zutshi M, Remzi FH et al (2007) A randomized multicenter trial to compare long-term functional outcome, quality of life, and complications of surgical procedures for low rectal cancers. Ann Surg 246(3):481–488PubMedCentral CrossRef PubMed
  48.Liao C, Gao F, Cao Y (2010) Meta-analysis of the colon J-Pouch vs transverse coloplasty pouch after anterior resection for rectal cancer. Colorectal Dis 12(7):624–631CrossRef PubMed
  49.Vennix S, Pelzers L, Bouvy N et al (2014) Laparoscopic versus open total mesorectal excision for rectal cancer. Cochrane Database Syst Rev 4:CD005200PubMed
  50.Späth C, Müller T, Nitsche U et al (2013) Minimalinvasive Chirurgie bei Malignomen des Gastrointestinaltraktes: Kolon-Pro-Position. Viszeralmedizin 29:382–387
  51.Martin ST, Heneghan HM, Winter DC (2012) Systematic review and meta-analysis of outcomes following pathological complete response to neoadjuvant chemoradiotherapy for rectal cancer. Br J Surg 99(7):918–928CrossRef PubMed
  52.Perez RO, Habr-Gama A, Sao Juliao GP et al (2012) Optimal timing for assessment of tumor response to neoadjuvant chemoradiation in patients with rectal cancer: do all patients benefit from waiting longer than 6 weeks? Int J Radiat Oncol Biol Phys 84(5):1159–1165CrossRef PubMed
  53.Sprawka A, Pietrzak L, Garmol D et al (2023) Definitive radical external beam radiotherapy for rectal cancer: evaluation of local effectiveness and risk of late small bowel damage. Acta Oncol 52(4):816–823CrossRef
  
• 作者单位：C. Rimkus (1)
  H. Seidl (2)
  W. Heiland (1)
  PD Dr. F. G. Bader (1)
  
  1. Klinik für Allgemein-, Viszeral- und minimalinvasive Chirurgie, Isar Klinikum, Sonnenstraße 24–26, 80331, München, Deutschland
  2. Klinik für Gastroenterologie, Hepatologie und Gastroenterologische Onkologie, Isar Klinikum, Sonnenstraße 24–26, 80331, München, Deutschland
  
• 刊物主题：Gastroenterology; General Practice / Family Medicine; Internal Medicine; Hepatology; Infectious Diseases; Oncology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1861-969X

文摘

Due to improved interdisciplinary staging, rectal cancer can be treated in a more individualized manner. Over the last decade, high-quality resection has reduced the incidence of local recurrence. In locally advanced situations, patients receive multimodal treatment, based on preoperative RTx/RCTx, which is completed with chemotherapy after the operation. Further studies concerning dose effects, changing chemotherapeutic agents, adding antibodies, and extending the total mesorectal excision (TME) technique to rectal cancer in the upper third to improve the efficiency of the multimodal therapy are in progress. Keywords Staging Prognosis Multimodal treatment Radiation Radiochemotherapy