Clinicopathologic features of primary colonic enteropathy-associated T cell lymphoma type II in an elderly Asian male with diarrhea

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• 作者：Jey-Hsin Chen (1) (2)
  Diane Bai (3)
  Vik Dabhi (4)
  Brent L. Wood (5) (6)
  Steven J. Kussick (7)
  
  1. CellNetix Pathology and Laboratories ; 1124 Columbia Street ; Suite 200 ; Seattle ; WA ; 98104 ; USA
  2. Swedish Medical Center ; Seattle ; WA ; USA
  3. Division of Gastroenterology ; Pacific Medical Center ; Seattle ; WA ; USA
  4. Division of Hematology and Oncology ; Pacific Medical Center ; Seattle ; WA ; USA
  5. Department of Laboratory Medicine ; University of Washington Medical Center ; Seattle ; WA ; USA
  6. Seattle Cancer Care Alliance ; Seattle ; WA ; USA
  7. PhenoPath Laboratories ; Seattle ; WA ; USA
  
• 关键词：Enteropathy ; associated T cell lymphoma (EATL) ; Primary intestinal T cell lymphoma (ITL) ; Monomorphic ; Cytotoxic T cells ; Natural killer (NK) cells
• 刊名：Journal of Hematopathology
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：8
• 期：1
• 页码：37-41
• 全文大小：1,096 KB
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  4. Chott, A, Haedicke, W, Mosberger, I, Fodinger, M, Winkler, K, Mannhalter, C (1998) Most CD56+ intestinal lymphomas are CD8鈥?鈥塁D5-T-cell lymphomas of monomorphic small to medium size histology. Am J Pathol 153: pp. 1483-1490 CrossRef
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  6. Chan JK, Chan AC, Cheuk W, Wan SK, Lee WK, Lui YH et al (2011) Type II enteropathy-associated T-cell lymphoma: a distinct aggressive lymphoma with frequent 纬未 T-cell receptor expression. Am J Surg Pathol 35:1557鈥?569
  7. Sun, J, Lu, Z, Yang, D, Chen, J (2011) Primary intestinal T-cell and NK-cell lymphomas: a clinicopathological and molecular study from China focused on type II enteropathy-associated T-cell lymphoma and primary intestinal NK-cell lymphoma. Mod Pathol 24: pp. 983-992 CrossRef
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  12. Tan SY, Chuang SS, Tang T, Tan L, Ko YH, Chuah KL et al (2013) Type II EATL (epitheliotropic intestinal T-cell lymphoma): a neoplasm of intra-epithelial T-cells with predominant CD8伪伪 phenotype. Leukemia 27:1688鈥?696
  13. Akiyama, T, Okino, T, Konishi, H, Wani, Y, Notohara, K, Tsukayama, C (2008) CD8+, CD56+ (natural killer-like) T-cell lymphoma involving the small intestine with no evidence of enteropathy: clinicopathology and molecular study of five Japanese patients. Pathol Int 58: pp. 626-634 CrossRef
  14. Takeshita, M, Nakamura, S, Kikuma, K, Nakayama, Y, Nimura, S, Yao, T (2011) Pathological and immunohistological findings and genetic aberrations of intestinal enteropathy-associated T cell lymphoma in Japan. Histopathology 58: pp. 395-407 CrossRef
  15. Kikuma, K, Yamada, K, Nakamura, S, Ogami, A, Nimura, S, Hirahashi, M (2014) Detailed clinicopathological characteristics and possible lymphomagenesis of type II intestinal enteropathy-associated T-cell lymphoma in Japan. Hum Pathol 45: pp. 1276-1284 CrossRef
  16. Kim, H, Lee, D, Kim, JW, Huh, J, Park, SH, Ha, HK (2014) Endoscopic and clinical analysis of primary T-cell lymphoma of the gastrointestinal tract according to pathological subtype. J Gastroenterol Hepatol 29: pp. 934-943 12471" target="_blank" title="It opens in new window">CrossRef
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• 刊物主题：Pathology; Hematology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1865-5785

文摘

A 76-year-old Asian man with a 6-month history of intractable watery diarrhea proceeded to colonoscopic examination that revealed diffusely dull-appearing colonic mucosa with focal areas of superficial ulceration. Mucosal biopsies demonstrated a neoplastic population of monomorphous small-to-intermediate-sized CD8+/CD56+ cytotoxic T cells that densely infiltrated the surface epithelium and crypts in a near pan-colonic distribution without tumor formation. Clinical staging revealed no disease elsewhere. The patient was treated aggressively with chemotherapy but died from disease five and a half months after presentation. In all likelihood, the patient had primary colonic involvement by enteropathy-associated T cell lymphoma (EATL) type II, a rare and aggressive extranodal non-Hodgkin lymphoma that occurs more commonly in Asians in whom celiac disease is infrequent. Widespread colonic disease in the absence of a mass-forming infiltrate has not been characterized in EATL type II and highlights an expanded clinical and pathological spectrum of the disease.