On the Significance of Exposure Time in Computational Blood Damage Estimation

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• 关键词：Computational hemodynamics ; Hemolysis modeling ; Ventricular assist device ; Finite element method ; Blood damage
• 刊名：Lecture Notes in Computer Science
• 出版年：2017
• 出版时间：2017
• 年：2017
• 卷：10164
• 期：1
• 页码：24-36
• 丛书名：High-Performance Scientific Computing
• ISBN：978-3-319-53862-4
• 卷排序：10164

文摘

The reliability of common stress-based power law models for hemolysis estimations in blood pumps is still not satisfying. Stress-based models are based on an instantaneous shear stress measure. Therefore, such models implicitly assume that red blood cells deform immediately due to the action of forces. In contrast, a strain-based model considers the entire deformation history of the cells. By applying a viscoelastic tensor equation for the stress computation, the effect of exposure time is represented as a biophysical phenomenon. Comparisons of stress-based and strain-based hemolysis models in a centrifugal blood pump show very significant differences. Stress peaks with short exposure time contribute to the overall hemolysis in the stress-based model, whereas regions with increased shear and long exposure time are responsible for damage in the strain-based model.