Synovial cytokine expression in ankle osteoarthritis depends on age and stage

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• 作者：Hagen Schmal ; Ralf Henkelmann…
• 关键词：Ankle ; Osteoarthritis ; Ankle Osteoarthritis Scoring System ; CD105 ; BMP ; 7 ; Aggrecan ; Biomarker ; bFGF ; Clinical trial
• 刊名：Knee Surgery, Sports Traumatology, Arthroscopy
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：23
• 期：5
• 页码：1359-1367
• 全文大小：461 KB
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• 作者单位：Hagen Schmal (1)
  Ralf Henkelmann (1)
  Alexander T. Mehlhorn (1)
  Kilian Reising (1)
  Gerrit Bode (1)
  Norbert P. Südkamp (1)
  Philipp Niemeyer (1)
  
  1. Department of Orthopaedic Surgery, University of Freiburg Medical Center, Hugstetter Str. 55, 79106, Freiburg i.Br., Germany
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Orthopedics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-7347

文摘

Purpose Aim of the study was the analysis of cytokine expression in ankle osteoarthritis (OA) hypothesizing age-dependent regulation patterns. Methods Forty-nine patients undergoing an arthroscopy of the ankle with different stages of chronic OA were prospectively included in a clinical trial comparing the group <18?years (n?=?9, ?15.1?±?2.0?years) with the older patients (?8?years, n?=?40, ?36.5?±?11.9). Lavage fluids were analysed by ELISA for levels of aggrecan, BMP-2/7, IGF-1/R, bFGF, CD105, MMP-13, and IL-1β. Additionally, clinical parameters and scores (FFI, CFSS, AOFAS) were evaluated and supplemented by radiographic scores [Kellgren–Lawrence Score (KLS) for conventional X-rays, Ankle Osteoarthritis Scoring System (AOSS) for MRI]. Results In contrast to distribution of gender and BMI (p?<?0.005), parameters characterizing the cartilage defect as ICRS grading, size, and duration of symptoms were not dependent on age. The incidence of osteochondritis dissecans (OCD) was higher in the group <18?years (p?<?0.006), but the average degree of OCD grading was not different. KLS and AOSS were significantly higher in the group ?8?years (p?<?0.02). Correlating with the higher degree of OA in the elderly, clinical function measured by FFI and AOFAS was statistically significantly worse (p?<?0.05). Intra-articular concentrations of aggrecan (3.1-fold), bFGF (8.7-fold), BMP-7 (2.7-fold), and CD105 (1.5-fold) were statistically significantly higher in the group??8?years (p?<?0.03). Conclusions Confirming the hypothesis, increased synovial levels of aggrecan, bFGF, BMP-7, and CD105 were found in patients over 18?years. This correlated with a higher stage of OA determined by radiographic changes or deteriorated function and may offer starting points for new diagnostics and interventional strategies. Level of evidence II.