Effects of raloxifene on normal breast tissue from premenopausal women

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• 作者：Benedito Borges da Silva ; Ione Maria Ribeiro Soares Lopes and Luiz Henrique Gebrim
• 关键词：breast ; breast cancer chemoprevention ; Ki ; 67 ; normal breast ; raloxifene
• 刊名：Breast Cancer Research and Treatment
• 出版年：2006
• 出版时间：January 2006
• 年：2006
• 卷：95
• 期：2
• 页码：99-103
• 全文大小：282 KB

文摘

The objective of this study was to evaluate the effects of raloxifene on normal breast tissue. A randomized, double-blind study was carried out in 30 ovulatory, premenopausal women of 18–40 years of age, who had been diagnosed with fibroadenoma of the breast. The patients were divided into two groups: Group A (placebo, n=16) and Group B (raloxifene 60 mg, n=14). The medication was given for 22 days, beginning on the first day of the menstrual cycle. An excisional biopsy was carried out on the 23rd day during which a sample of normal breast tissue was collected to evaluate the presence of the proliferating cell marker Ki-67. Student’s t-test was used for the statistical analysis of data (p<0.05). Mean percentage of stained nuclei in groups A and B was 10.96 ¡À 1.27 and 1.21 ¡À 0.26, respectively (p<0.001). Raloxifene significantly reduced the proliferative activity of normal breast tissue in premenopausal women.