Retinal function in patients treated with tamoxifen

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• 作者：Sung Eun Song Watanabe ; Adriana Berezovsky ; M¨¢rcia Motono ; Paula Yuri Sacai ; Josenilson Martins Pereira ; Juliana Maria Ferraz Sallum ; Luiz Henrique Gebrim and Solange Rios Salom?o
• 关键词：Tamoxifen ; Retinal toxicity ; Electroretinography ; Breast cancer
• 刊名：Documenta Ophthalmologica
• 出版年：2010
• 出版时间：April, 2010
• 年：2010
• 卷：120
• 期：2
• 页码：137-143
• 全文大小：261.7 KB

文摘

Tamoxifen, an effective treatment of breast cancer, has been shown to cause ocular toxic effects. The purpose of this study was to determine retinal toxicity by full-field and focal electroretinograms (ERGs) in patients treated with tamoxifen. Full-field and focal ERGs were obtained from three groups: Tamoxifen—14 females (47–72 years, mean 58.3 ¡À 9.1) with normal fundus, treated with tamoxifen from 2 to 37 months; No Treatment—10 females (39–65 years, mean 50.1 ¡À 8.7) with previous breast cancer diagnosis and before tamoxifen treatment; Control—13 normal female volunteers (41–81 years, mean 52.7 ¡À 12.1). Peak-to-peak amplitude and b-wave implicit time were measured and statistically analyzed. Mean peak-to-peak amplitudes and implicit time from full-field and focal ERGs were comparable for the three different groups. Low-dosage tamoxifen showed no retinotoxic effect assessed by full-field and focal ERG in this small group of women with breast cancer.