Mechanism of action and efficacy of RX-111, a thieno[2,3-c]pyridine derivative and small molecule inhibitor of protein interaction with glycosaminoglycans (SMIGs), in delayed-type hypersensitivity, TNBS-induced colitis and experimental autoimmune encepha

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• 作者：Nicholas Harris ; Juraj Koppel ; Ferenc Zsila ; Stefan Juhas…
• 关键词：Small molecule drug ; Glycosaminoglycan ; Heparin binding protein ; Heparan sulfate ; Inflammation ; Autoimmune disease
• 刊名：Inflammation Research
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：65
• 期：4
• 页码：285-294
• 全文大小：1,013 KB
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• 作者单位：Nicholas Harris (1) (2)
  Juraj Koppel (3)
  Ferenc Zsila (4)
  Stefan Juhas (3) (8)
  Gabriela Il’kova (3) (7)
  Faina Yurgenzon Kogan (1)
  Orly Lahmy (1)
  Gizi Wildbaum (5)
  Nathan Karin (5)
  Regina Zhuk (1)
  Paul Gregor (1) (6)
  
  1. Rimonyx Pharmaceuticals Ltd., Rabin Science Park, 70400, Ness-Ziona, Israel
  2. Ephraim Katzir Department of Biotechnology Engineering, ORT Braude Academic College of Engineering, 21982, Karmiel, Israel
  3. Institute of Animal Physiology, Slovak Academy of Sciences, 04001, Kosice, Slovakia
  4. Biomolecular Self-Assembly Group, Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Budapest, Hungary
  8. Institute of Animal Physiology and Genetics of the ASCR, v. v. i., Rumburská 89, 277 21, Liběchov, Czech Republic
  7. GYN-FIV a.s., Záhradnícka 42, 821 085, Bratislava, Slovakia
  5. Department of Immunology, Rappaport Institute, Rappaport Faculty of Medicine, Technion, Haifa, Israel
  6. GISMO Therapeutics Inc., A253 ASTECC-UK, Lexington, KY, 40506, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Immunology
  Pharmacology and Toxicology
  Allergology
  Dermatology
  Neurology
  Rheumatology
  
• 出版者：Birkh盲user Basel
• ISSN：1420-908X

文摘

Objective and design Elucidate the mechanism of action of the small molecule inhibitor of protein binding to glycosaminoglycans, RX-111 and assay its anti-inflammatory activity in animal models of inflammatory disease.