Expression and significance of fgl2 prothrombinase in cardiac microvascular endothelial cells of rats with type 2 diabetes
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  • 作者:Yanping Ding (1)
    Kun Liu (1)
    Yan Wang (1)
    Guanhua Su (1)
    Heping Deng (2)
    Qiutang Zeng (1)
    Yuhua Liao (1)
    Zhaohui Wang (1)
  • 关键词:fibrinogen ; like protein 2 ; type 2 diabetes ; ischemic heart disease ; microangiopathy ; tumor necrosis factor ; α ; cardiac function
  • 刊名:Journal of Huazhong University of Science and Technology [Medical Sciences]
  • 出版年:2010
  • 出版时间:October 2010
  • 年:2010
  • 卷:30
  • 期:5
  • 页码:575-581
  • 全文大小:668KB
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    7. Chan CW, Chan MW, Liu M, / et al. Kinetic analysis of a unique direct prothrombinase, fgl2, and identification of a serine residue critical for the prothrombinase activity. J Immunol, 2002,168(10):5170-177
    8. Ding JW, Ning Q, Liu MF, / et al. Fulminant hepatic failure in murine hepatitis virus strain 3 infection: Tissue-specific expression of a novel fgl2 prothrombinase. J Virol, 1997,71(12):9223-230
    9. Marsden PA, Ning Q, Fung LS, / et al. The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis. J Clin Invest, 2003,112(1):58-6
    10. Ghanekar A, Mendicino M, Liu H, / et al. Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection. J Immunol, 2004,172(9): 5693-701
    11. Mendicino M, Liu M, Ghanekar A, / et al. Targeted deletion of Fgl-2/fibroleukin in the donor modulates immunologic response and acute vascular rejection in cardiac xenografts. Circulation, 2005,112(2):248-56 CrossRef
    12. Clark DA, Ding JW, Chaouat G, / et al. The emerging role of immunoregulation of fibrinogen-related procoagulant Fgl2 in the success or spontaneous abortion of early pregnancy in mice and humans. Am J Reprod Immunol, 1999,42(1):37-3
    13. Knackstedt MK, Zenclussen AC, Hertwig K, / et al. Th1 cytokines and the prothrombinase fgl2 in stress-tri ggered and inflammatory abortion. Am J Reprod Immunol, 2003,49(4):210-20 CrossRef
    14. Clark DA, Foerster K, Fung L, / et al. The fgl2 prothrombinase/fibroleukin gene is required for lipopolysaccharide-triggered abortions and for normal mouse reproduction. Mol Hum Reprod, 2004,10(2):99-08 CrossRef
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    18. Ning Q, Brown D, Parodo J, / et al. Ribavirin inhibits viral-induced macrophage production of TNF-α, IL-1, the procoagulant fgl2 prothrombinase and preserves Th1 cytokine production but inhibits Th2 cytokine response. J Immunol, 1998,160(7):3487-493
    19. Clark DA, Chaouat G, Arck PC, / et al. Cytokine-dependent abortion in CBA × DBA/2 mice is mediated by the procoagulant fgl2 prothrombinase [correction of prothombinase]. J Immunol, 1998,160(2): 545-49
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  • 作者单位:Yanping Ding (1)
    Kun Liu (1)
    Yan Wang (1)
    Guanhua Su (1)
    Heping Deng (2)
    Qiutang Zeng (1)
    Yuhua Liao (1)
    Zhaohui Wang (1)

    1. Department of Cardiology, Huazhong University of Science and Technology, Wuhan, 430022, China
    2. Department of Ultrasonic Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
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