Quantitative [¹⁸F]FMISO PET Imaging Shows Reduction of Hypoxia Following Trastuzumab in a Murine Model of HER2+ Breast Cancer

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• 作者：Anna G. Sorace ; Anum K. Syed ; Stephanie L. Barnes…
• 关键词：Key wordsFMISO ; Oxygenation ; Vascular maturation ; Herceptin ; BT474 ; Pimonidazole ; Misonidazole
• 刊名：Molecular Imaging and Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：19
• 期：1
• 页码：130-137
• 全文大小：
• 刊物主题：Imaging / Radiology;
• 出版者：Springer US
• ISSN：1860-2002
• 卷排序：19

文摘

PurposeEvaluation of [18F]fluoromisonidazole ([18F]FMISO)-positron emission tomography (PET) imaging as a metric for evaluating early response to trastuzumab therapy with histological validation in a murine model of HER2+ breast cancer.