What’s new in using platelet research? To unravel thrombopathies and other human disorders

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• 作者：Kathleen Freson (1)
  Veerle Labarque (1) (2)
  Chantal Thys (1)
  Christine Wittevrongel (1)
  Chris Van Geet (1) (2)
  
• 关键词：Platelets ; G protein signalling ; Adhesion ; Secretion ; Cytoskeleton
• 刊名：European Journal of Pediatrics
• 出版年：2007
• 出版时间：December 2007
• 年：2007
• 卷：166
• 期：12
• 页码：1203-1210
• 全文大小：272KB
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• 作者单位：Kathleen Freson (1)
  Veerle Labarque (1) (2)
  Chantal Thys (1)
  Christine Wittevrongel (1)
  Chris Van Geet (1) (2)
  
  1. Center for Molecular and Vascular Biology, University of Leuven, Herestraat 49, 3000, Leuven, Belgium
  2. Department of Pediatrics, University of Leuven, Leuven, Belgium
  

文摘

This review on platelet research focuses on defects of adhesion, cytoskeletal organisation, signal transduction and secretion. Platelet defects can be studied by different laboratory platelet functional assays and morphological studies. Easy bruising or a suspected platelet-based bleeding disorder is of course the most obvious reason to test the platelet function in a patient. However, nowadays platelet research also contributes to our understanding of human pathology in other disciplines such as neurology, nephrology, endocrinology and metabolic diseases. Apart from a discussion on classical thrombopathies, this review will also deal with the less commonly known relation between platelet research and disorders with a broader clinical phenotype. Classical thrombopathies involve disorders of platelet adhesion such as Glanzmann thrombastenia and Bernard-Soulier syndrome, defective G protein signalling diseases with impaired phospholipase C activation, and abnormal platelet granule secretion disorders such as gray platelet disorder and delta-storage pool disease. Other clinical symptoms besides a bleeding tendency have been described in MYH9-related disorders and Duchenne muscular dystrophy due to adhesion defects, and also in disorders of impaired Gs signalling, in Hermansky Pudlack disease and Chediak Higashi disease with abnormal secretion. Finally, platelet research can also be used to unravel novel mechanisms involved in many neurological disorders such as depression and autism with only a subclinical platelet defect.