In vivo comparison of biomineralized scaffold-directed osteogenic differentiation of human embryonic and mesenchymal stem cells

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• 作者：Cai Wen ; Heemin Kang ; Yu-Ru V. Shih…
• 关键词：Embryonic stem cells ; Mesenchymal stem cells ; In vivo osteogenic differentiation ; Biomineralized scaffold ; Bone tissue engineering ; Calcium phosphate
• 刊名：Drug Delivery and Translational Research
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：6
• 期：2
• 页码：121-131
• 全文大小：2,417 KB
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• 作者单位：Cai Wen (1)
  Heemin Kang (2)
  Yu-Ru V. Shih (2)
  YongSung Hwang (2)
  Shyni Varghese (2)
  
  1. School of Chemistry and Chemical Engineering, Southeast University, Sipailou 2#, Nanjing, Jiangsu Province, 210096, People’s Republic of China
  2. Department of Bioengineering, University of California— San Diego, 9500, Gilman Drive, La Jolla, CA, 92093-0412, USA
  
• 刊物主题：Pharmaceutical Sciences/Technology;
• 出版者：Springer US
• ISSN：2190-3948

文摘

Human pluripotent stem cells such as embryonic stem cells (hESCs) and multipotent stem cells like mesenchymal stem cells (hMSCs) hold great promise as potential cell sources for bone tissue regeneration. Comparing the in vivo osteogenesis of hESCs and hMSCs by biomaterial-based cues provides insight into the differentiation kinetics of these cells as well as their potential to contribute to bone tissue repair in vivo. Here, we compared in vivo osteogenic differentiation of hESCs and hMSCs within osteoinductive calcium phosphate (CaP)-bearing biomineralized scaffolds that recapitulate a bone-specific mineral microenvironment. Both hESCs and hMSCs underwent osteogenic differentiation responding to the biomaterial-based instructive cues. Furthermore, hMSCs underwent earlier in vivo osteogenesis compared to hESCs, but both stem cell types acquired a similar osteogenic maturation by 8 weeks of implantation.