Constituents from Vitex negundo var. heterophylla and their inhibition of nitric oxide production
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- 作者：Chongyue Qiu ; Liang Tong ; Ting Yuan ; Fei Wang ; Feng Zhao…
- 关键词：Vitex negundo var. heterophylla ; Iridoid ; Phenol ; Nitric oxide ; Molecular docking
- 刊名：Journal of Natural Medicines
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：71
- 期：1
- 页码：292-298
- 全文大小：
- 刊物主题：Pharmacology/Toxicology; Plant Sciences; Complementary & Alternative Medicine; Medicinal Chemistry; Pharmacy;
- 出版者：Springer Japan
- ISSN：1861-0293
- 卷排序：71
文摘
An iridoid glucoside, 10-p-hydroxybenzoyl-6β-hydroxyiridoid 1-O-β-d-(6′-O-p-hydroxybenzoyl)-glucopyranoside (1), and a phenol glucoside, 4-hydroxyphenethanol 3-O-β-d-(6′-O-p-hydroxybenzoyl)-glucopyranoside (2), along with nine known compounds (3–11) were isolated from the dried leaves of Vitex negundo var. heterophylla. Their structures were elucidated by extensive analysis of NMR spectra. All of the isolated compounds were evaluated for their inhibitory effects on nitric oxide production in RAW 264.7 macrophages. Compounds 2 and 3 exhibited obvious inhibitory effects on NO production with IC50 values of 30.76 and 49.89 μM, respectively. Molecular docking studies of compounds 2 and 3 with nitric oxide synthase (NOS) further confirmed the above results.