Multi-class method for biomonitoring of hair samples using gas chromatography-mass spectrometry

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• 作者：Julia Martín ; Monika Möder ; Alexander Gaudl…
• 关键词：Emerging pollutants ; Hair analysis ; Gas chromatography–mass spectrometry ; Human biomonitoring
• 刊名：Analytical and Bioanalytical Chemistry
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：407
• 期：29
• 页码：8725-8734
• 全文大小：992 KB
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• 作者单位：Julia Martín (1)
  Monika Möder (2)
  Alexander Gaudl (3)
  Esteban Alonso (1)
  Thorsten Reemtsma (2)
  
  1. Department of Analytical Chemistry, Escuela Politécnica Superior, University of Seville, C/ Virgen de África 7, 41011, Seville, Spain
  2. Department of Analytical Chemistry, Helmholtz Centre for Environmental Research - UFZ, Permoserstraße 15, 04318, Leipzig, Germany
  3. Institute of Laboratory Medicine, University of Leipzig, Liebigstraße 27b, 04103, Leipzig, Germany
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Food Science
  Inorganic Chemistry
  Physical Chemistry
  Monitoring, Environmental Analysis and Environmental Ecotoxicology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1618-2650

文摘

Currently, non-invasive biomonitoring of human exposure to organic pollutants bases upon the analysis mainly of urine and human breast milk. While mostly persistent organic pollutants are the center of interest, the aim of our study was to develop a method for the determination of different chemical classes of emerging pollutants (organophosphorus flame retardants, plastic additives such as phthalates, bisphenol A, insecticides, antimicrobials, preservatives and musk fragrances) in hair by gas chromatography–mass spectrometry. The preferred sample preparation included hydrolysis of the hair with trifluoroacetic acid in methanol followed by a liquid–liquid extraction using hexane/ethyl acetate. The validated method is characterized by recoveries higher than 77 % for most analytes, relative standard deviations below 16 % and limits of detection between 2 pg mg−1 (HHCB) and 292 pg mg−1 (propylparaben) using 50 mg of dry hair. After respective blank corrections, bis-(2-ethylhexyl)phthalate (DEHP) and the musk fragrance HHCB were the predominant compounds determined in all hair samples at concentrations between 32 and 59 ng mg−1 and 0.8–13 ng mg−1, respectively. The bactericide triclosan and the insect repellent N,N-diethyl-3-methylbenzamide (DEET) were detected in selected hair samples at 2 and 0.8 ng mg−1, respectively.